A Unified Mechanism for Abiotic Adenine and Purine Synthesis in Formamide

被引：64

作者：

Hudson, Jeremy S. ^{[1
]}

Eberle, Joseph F. ^{[1
]}

Vachhani, Raj H. ^{[1
]}

Rogers, Luther C. ^{[1
]}

Wade, James H. ^{[1
]}

Krishnamurthy, Ramanarayanan ^{[2
]}

Springsteen, Greg ^{[1
]}

机构：

[1] Furman Univ, Dept Chem, Greenville, SC 29613 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 21期

关键词：

cyanides; formamide; nucleobases; prebiotic chemistry; purines; PRIMITIVE EARTH CONDITIONS; ONE-STEP SYNTHESIS; PREBIOTIC SYNTHESIS; HYDROGEN-CYANIDE; NUCLEIC-ACIDS; NUCLEOBASES; ORIGIN; LIFE; CHEMISTRY; 4-AMINO-5-CYANOIMIDAZOLE;

D O I：

10.1002/anie.201108907

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Form(am)idable beginning: Mechanistic pathways from formamide to purine and adenine have been proposed (see scheme, purine (R=H, X=H), adenine (R=CN, X=NH 2, R'=CONH 2). Parallels between these plausible prebiotic syntheses and purine-ring biosynthesis may allude to the origins of the metabolic route. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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页码：5134 / 5137

页数：4

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