Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice

被引：26
作者：
Norton, Brianna L. [1 ]
Akiyama, Matthew J. [1 ]
Zamor, Philippe J. [2 ]
Litwin, Alain H. [1 ]
机构：
[1] Montefiore Med Ctr, Albert Einstein Coll Med, Div Gen Internal Med, 3300 Kossuth Ave, Bronx, NY 10467 USA
[2] Carolinas Healthcare Syst, Div Hepatol, 1025 Morehead Med Dr,Suite 600, Charlotte, NC 28204 USA
来源：
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2018年 / 32卷 / 02期
关键词：
Hepatitis C virus; Opioid agonist therapy; Drug-drug interactions; Direct acting antivirals; Best practice; INJECTION-DRUG USERS; METHADONE-MAINTENANCE TREATMENT; SUSTAINED VIROLOGICAL RESPONSE; ALL-CAUSE MORTALITY; VIRUS-INFECTION; SUBSTITUTION THERAPY; PLUS RIBAVIRIN; UNITED-STATES; PHARMACOKINETIC INTERACTION; SUBSTANCE USE;
D O I：
10.1016/j.idc.2018.02.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Injection drug use is the most common transmission route for hepatitis C. High rates of infection are observed among individuals on opioid agonist therapy. Although people who inject drugs carry the highest burden, few have initiated treatment. The authors present a comprehensive review of the evidence on the efficacy of HCV medications, drug-drug interactions, and barriers to and models of care. Studies have demonstrated comparable efficacy for individuals who are on opioid agonist therapy compared with those who are not. We propose that a strategy of treatment and cure-as-prevention is imperative in this population to curb the hepatitis C epidemic.
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收藏
页码：347 / +
页数：26
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