Developments in X-ray Crystallographic Structure Determination of Biological Macromolecules

被引：113

作者：

Garman, Elspeth F. ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

来源：

SCIENCE | 2014年 / 343卷 / 6175期

关键词：

PROTEIN CRYSTALS; ANOMALOUS DIFFRACTION; ROOM-TEMPERATURE; RADIATION-DAMAGE; SOFTWARE; REFINEMENT; COMPLEX; LASER;

D O I：

10.1126/science.1247829

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The three-dimensional structures of large biomolecules important in the function and mechanistic pathways of all living systems and viruses can be determined by x-ray diffraction from crystals of these molecules and their complexes. This area of crystallography is continually expanding and evolving, and the introduction of new methods that use the latest technology is allowing the elucidation of ever larger and more complex biological systems, which are now becoming tractable to structure solution. This review looks back at what has been achieved and forward at how current and future developments may allow technical challenges to be overcome.

引用

页码：1102 / 1108

页数：7

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