Asymmetric Synthesis of α-Alkylated Aldehydes using Terminal Epoxide-Derived Chiral Enamines

被引：25

作者：

Hodgson, David M. ^{[1
]}

Kaka, Naeem S. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 51期

基金：

英国工程与自然科学研究理事会;

关键词：

aldehydes; alkylation; asymmetric synthesis; enamines; terminal epoxides;

D O I：

10.1002/anie.200804369

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Effective discrimination: Efficient lithium amide-induced terminal epoxide-enamine transformation provides the first enamines capable of generating α-alkylated aldehydes with high asymmetric induction by intermolecular nucleophilic substitution (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9958 / 9960

页数：3

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