Asymmetric Synthesis of α-Alkylated Aldehydes using Terminal Epoxide-Derived Chiral Enamines

被引：25
|
作者：
Hodgson, David M. [1 ]
Kaka, Naeem S. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 51期
基金：
英国工程与自然科学研究理事会;
关键词：
aldehydes; alkylation; asymmetric synthesis; enamines; terminal epoxides;
D O I：
10.1002/anie.200804369
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Effective discrimination: Efficient lithium amide-induced terminal epoxide-enamine transformation provides the first enamines capable of generating α-alkylated aldehydes with high asymmetric induction by intermolecular nucleophilic substitution (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9958 / 9960
页数：3
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