High-density peptide arrays

被引：34

作者：

Breitling, Frank ^{[1
]}

Nesterov, Alexander ^{[1
]}

Stadler, Volker ^{[1
]}

Felgenhauer, Thomas ^{[1
]}

Bischoff, F. Ralf ^{[1
]}

机构：

[1] German Canc Res Ctr, D-6900 Heidelberg, Germany

来源：

MOLECULAR BIOSYSTEMS | 2009年 / 5卷 / 03期

关键词：

SPOT-SYNTHESIS; COMBINATORIAL SYNTHESIS; PARALLEL; EXPRESSION; FABRICATION; DISPLAY; MICROARRAYS; GENERATION; ANTIGENS; LIBRARY;

D O I：

10.1039/b819850k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arrays promise to advance biology by allowing parallel screening for many different binding partners. Meanwhile, lithographic methods enable combinatorial synthesis of > 50 000 oligonucleotides per cm(2), an advance that has revolutionized the whole field of genomics. A similar development is expected for the field of proteomics, provided that affordable, very high-density peptide arrays are available. However, peptide arrays lag behind oligonucleotide arrays. This review discusses recent developments in the field with an emphasis on methods that lead to very high-density peptide arrays.

引用

页码：224 / 234

页数：11

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