Cerebrospinal fluid anandamide levels, cannabis use and psychotic-like symptoms

被引：73
作者：
Morgan, Celia J. A. [1 ]
Page, Emma [1 ]
Schaefer, Carola [2 ]
Chatten, Katharine [3 ]
Manocha, Amod [3 ]
Gulati, Sumit [3 ]
Curran, H. Valerie [1 ]
Brandner, Brigitta [3 ]
Leweke, F. Markus [2 ]
机构：
[1] UCL, Clin Psychopharmacol Unit, London WC1E 6BT, England
[2] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany
[3] UCL Hosp Trust, Ctr Anaesthesia, London, England
来源：
BRITISH JOURNAL OF PSYCHIATRY | 2013年 / 202卷 / 05期
关键词：
STATES;
D O I：
10.1192/bjp.bp.112.121178
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Anandamide is a ligand of the endocannabinoid system. Animals show a depletion following repeated Delta(9)-tetrahydrocannabinol (THC) administration but the effect of cannabis use on central nervous system levels of endocannabinoids has not been previously examined in humans. Cerebrospinal fluid (CSF) levels of the endocannabinoids anandamide, 2-arachidonoylglycerol (2-AG) and related lipids were tested in 33 volunteers (20 cannabis users). Lower levels of CSF anandamide and higher levels of 2-AG in serum were observed in frequent compared with infrequent cannabis users. Levels of CSF anandamide were negatively correlated with persisting psychotic symptoms when drug-free. Higher levels of anandamide are associated with a lower risk of psychotic symptoms following cannabis use.
引用
收藏
页码：381 / 382
页数：2
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