Palladium-Mediated [11C]Carbonylation at Atmospheric Pressure: A General Method Using Xantphos as Supporting Ligand

被引：75

作者：

Dahl, Kenneth ^{[1
]}

Schou, Magnus ^{[1
,2
]}

Amini, Nahid ^{[1
]}

Halldin, Christer ^{[1
]}

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Karolinska Hosp, S-17176 Stockholm, Sweden

[2] Karolinska Hosp, AstraZeneca Translat Sci Ctr, PET Ctr Excellence, Dept Clin Neurosci,Ctr Psychiat Res, S-17176 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 07期

关键词：

Isotopic labeling; Radiolabeling; Radiochemistry; Carbonylation; Positron emission tomography; CATALYZED CARBONYLATION REACTIONS; COUPLING REACTIONS; WEINREB AMIDES; ARYL BROMIDES; C-11; AMINOCARBONYLATION; CHEMISTRY; MONOXIDE; HALIDES;

D O I：

10.1002/ejoc.201201708

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed [C-11]carbonylation of aryl halides and triflates was achieved at atmospheric pressure by employing xantphos as the supporting ligand. Aryl halides were converted into their corresponding [C-11]amides in good to excellent yields. The conditions were also successfully employed in the radiolabeling of an [C-11]ester, a [C-11]carboxylic acid, an [C-11]aldehyde, and a [C-11]ketone.

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页码：1228 / 1231

页数：4

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