Gold(I)-Catalyzed Rearrangement of N-Aryl 2-Alkynylazetidines to Pyrrolo[1,2-a]indoles

被引：37

作者：

Kern, Nicolas ^{[1
]}

Hoffmann, Marie ^{[1
]}

Blanc, Aurelien ^{[1
]}

Weibel, Jean-Marc ^{[1
]}

Pale, Patrick ^{[1
]}

机构：

[1] Univ Strasbourg, Inst Chim, CNRS, Lab Synth Reactivite Organ & Catalyse, F-67070 Strasbourg, France

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 04期

关键词：

CLAISEN REARRANGEMENT; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; GOLD CATALYSIS; ANTIBIOTICS;

D O I：

10.1021/ol303518n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various N-aryl-2-alkynylazetidines were very efficiently converted to pyrrolo[1,2-a]indoles with gold catalysts, especially the 2-biphenyl-dicyclohexylphosphino-gold(I) hexafluoroantimonate, in dichloromethane at room temperature. Additionally, two formal syntheses of bioactive non-natural compounds, i.e. 7-methoxymitosene and an 5-HT2c receptor agonist, have been achieved.

引用

页码：836 / 839

页数：4

共 42 条

[1] MITOMYCIN ANTIBIOTICS . SYNTHETIC STUDIES .2. SYNTHESIS OF 7-METHOXYMITOSENE ANTIBACTERIAL AGENT [J].