Premature Atherosclerosis in Children With Transfusion-Dependent Thalassemia: A Twin-Center Cross-Sectional Study

被引：4
作者：
Kumaravel, K. S. [1 ]
Sampathkumar, D. [2 ]
Punitha, P. [2 ]
Anurekha, V. [2 ]
Hema, M. [1 ]
Rameshbabu, B. [2 ,3 ]
机构：
[1] Govt Mohan Kumaramangalam Med Coll, Dept Pediat, Salem, Tamil Nadu, India
[2] Govt Dharmapuri Med Coll, Dept Pediat, Dharmapuri 636701, Tamil Nadu, India
[3] Govt Dharmapuri Med Coll, Dept Pediat, Dharmapuri 636701, Tamil Nadu, India
来源：
INDIAN PEDIATRICS | 2022年 / 59卷 / 12期
关键词：
Complications; Ferritin; Outcome; Survival; INTIMA-MEDIA THICKNESS; SUBCLINICAL ATHEROSCLEROSIS; DYSFUNCTION;
D O I：
10.1007/s13312-022-2664-5
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Objective To analyze the risk of premature atherosclerosis in children with transfusion-dependent thalassemia (TDT) compared to controls by measuring carotid intima-media thickness (CIMT) and correlating it with clinical and biochemical parameters. Methods Case-control study among children aged 2 to 15 years. Results Significantly higher CIMT values were observed across all age groups. Mean (SD) CIMT in controls were 0.27(0.07) mm, 0.39 (0.03) mm, and 0.46 (0.05) mm in 2 to 5 years, 6 to 10 years, and 11 to 15 years age groups respectively, as against 0.43 (0.08) mm, 0.55 (0.07) mm and 0.63 (0.08) mm in cases in similar age groups (P < 0.001). Mean triglycerides and liver enzymes were significantly elevated in cases. Logistic regression analysis demonstrated that older age group and higher serum ferritin levels, but not dyslipidemia, were significantly associated with high CIMT. Conclusion Children with TDT are at increased risk for premature atherosclerosis.
引用
收藏
页码：925 / 928
页数：4
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