The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis

被引：102

作者：

Yuan, Yu ^{[1
]}

Chen, Xi ^{[1
]}

Zhang, Lingli ^{[1
]}

Wu, Juanni ^{[1
]}

Guo, Jianming ^{[1
]}

Zou, Dongchen ^{[2
]}

Chen, Binglin ^{[1
]}

Sun, Zhongguang ^{[1
]}

Shen, Chao ^{[1
]}

Zou, Jun ^{[1
]}

机构：

[1] Shanghai Univ Sport, Sch Kinesiol, Shanghai, Peoples R China

[2] Shanghai Foreign Language Sch, Shanghai, Peoples R China

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2016年 / 122卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Exercise; Mesenchymal stem cells; Osteoblasts; Osteocytes; Osteoclasts; Osteoporosis; Mechanical loading; MESENCHYMAL STEM-CELLS; OSTEOBLAST-LIKE CELLS; PROSTAGLANDIN E-2 PGE(2); MARROW STROMAL CELLS; HIGH-IMPACT EXERCISE; MECHANICAL STRAIN; TRABECULAR BONE; OSTEOGENIC DIFFERENTIATION; SIGNALING PATHWAYS; PHYSICAL-ACTIVITY;

D O I：

10.1016/j.pbiomolbio.2015.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With a rapid increase in the aging population, osteoporosis has become a global health problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be completely cured. Exercise is an economical, efficacious, and safe way to prevent the development of osteoporosis. Recent studies have investigated the mechanisms by which exercise affects bone remodeling. Here we update the progress made on the effects of exercise on bone cells, including bone marrow mesenchymal stem cells, osteoblasts, osteocytes, and osteoclasts, as well as on bone mass, bone strength, and geometry, hoping to provide a theoretical basis to improve osteoporosis prevention and treatment with exercise. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：122 / 130

页数：9

共 113 条

[1] The Influence of High-Impact Exercise on Cortical and Trabecular Bone Mineral Content and 3D Distribution Across the Proximal Femur in Older Men: A Randomized Controlled Unilateral Intervention [J].

Allison, Sarah J. ;

Poole, Kenneth E. S. ;

Treece, Graham M. ;

Gee, Andrew H. ;

Tonkin, Carol ;

Rennie, Winston J. ;

Folland, Jonathan P. ;

Summers, Gregory D. ;

Brooke-Wavell, Katherine .

JOURNAL OF BONE AND MINERAL RESEARCH, 2015, 30 (09) :1709-1716

[2] Non-Canonical Wnt Signaling and N-Cadherin Related β-Catenin Signaling Play a Role in Mechanically Induced Osteogenic Cell Fate [J].

Arnsdorf, Emily J. ;

Tummala, Padmaja ;

Jacobs, Christopher R. .

PLOS ONE, 2009, 4 (04)

[3] The Effect of Estrogen on Bone Marrow-Derived Rat Mesenchymal Stem Cell Maintenance: Inhibiting Apoptosis Through the Expression of Bcl-xL and Bcl-2 [J].

Ayaloglu-Butun, Fatma ;

Terzioglu-Kara, Ece ;

Tokcaer-Keskin, Zeynep ;

Akcali, Kamil Can .

STEM CELL REVIEWS AND REPORTS, 2012, 8 (02) :393-401

[4] High bone mass in mice expressing a mutant LRP5 gene [J].

Babij, P ;

Zhao, WG ;

Small, C ;

Kharode, Y ;

Yaworsky, PJ ;

Bouxsein, ML ;

Reddy, PS ;

Bodine, PVN ;

Robinson, JA ;

Bhat, B ;

Marzolf, J ;

Moran, RA ;

Bex, F .

JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (06) :960-974

[5] Physical training increases osteoprotegerin in postmenopausal women [J].

Bergstrom, Ingrid ;

Parini, Paolo ;

Gustafsson, Sven A. ;

Andersson, Goran ;

Brinck, Jonas .

JOURNAL OF BONE AND MINERAL METABOLISM, 2012, 30 (02) :202-207

[6] Dose-Dependent Effects of Triiodothyronine on the Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells [J].

Boeloni, J. N. ;

Ocarino, N. M. ;

Melo, A. B. ;

Silva, J. F. ;

Castanheira, P. ;

Goes, A. M. ;

Serakides, R. .

HORMONE RESEARCH, 2009, 72 (02) :88-97

[7] Osteocytes, mechanosensing and Wnt signaling [J].

Bonewald, Lynda F. ;

Johnson, Mark L. .

BONE, 2008, 42 (04) :606-615

[8] The Amazing Osteocyte [J].

Bonewald, Lynda F. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (02) :229-238

[9] Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model [J].

Boudenot, A. ;

Presle, N. ;

Uzbekov, R. ;

Toumi, H. ;

Pallu, S. ;

Lespessailles, E. .

OSTEOARTHRITIS AND CARTILAGE, 2014, 22 (08) :1176-1185

[10] Treadmill training regulates β-catenin signaling through phosphorylation of GSK-3β in lumbar vertebrae of ovariectomized rats [J].

Bu, Shumin ;

Chen, Yu ;

Wang, Shouhui ;

Zhang, Fan ;

Ji, Gang .

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2012, 112 (09) :3295-3304

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