Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal

被引：21

作者：

Liang, Yan ^{[1
]}

Fu, Xiaoheng ^{[2
]}

Du, Chen ^{[1
]}

Xia, Haoran ^{[1
]}

Lai, Yusi ^{[3
]}

Sun, Yong ^{[1
]}

机构：

[1] Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao, Peoples R China

[2] Hosp Peoples Liberat Army Navy, Dept Clin Lab, Qingdao, Peoples R China

[3] Sichuan Kelun Pharmaceut Co Ltd, Dept Mkt, Chengdu, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2020年 / 48卷 / 01期

基金：

美国国家科学基金会;

关键词：

Doxorubicin nanocrystal; chondroitin sulphate; target; drug delivery; POLYMERIC NANOPARTICLES; CHEMOTHERAPY; MICELLES; MOIETIES; PRODRUG; VECTOR;

D O I：

10.1080/21691401.2020.1813741

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this paper, we developed a novel strategy of preparing doxorubicin (DOX) nanocrystal (NC) exerting spherical particles with a diameter of 102 nm, which experienced following coating of chondroitin sulphate derivative (CSOA) shellviaelectrostatic and hydrophobic interactions. Such multifunctional outerwear resulted in drug nanocapsules with high drug loading content up to 70% and high colloidal stability under physiological conditions. It exhibited accelerated drug release behaviour when dispersing in hyaluronidase (HAase) containing medium or incubated with cancer cells. CSOA/NCs were effectively taken up by cancer cellsviaCD44 receptor-mediated endocytosis, but were rarely internalised into normal fibroblasts. With the comparison of typical drug-loaded micelles system (DOX/PEG-PCL), CSOA/NCs showed greater inhibition to cancer cells due to the targeted and sensitive drug delivery.

引用

页码：1114 / 1124

页数：11

共 22 条

[1] PolyMPC-Doxorubicin Prodrugs [J].

Chen, Xiangji ;

Parelkar, Sangram S. ;

Henchey, Elizabeth ;

Schneider, Sallie ;

Emrick, Todd .

BIOCONJUGATE CHEMISTRY, 2012, 23 (09) :1753-1763

[2] Cellular uptake, intracellular trafficking, and antitumor efficacy of doxorubicin-loaded reduction-sensitive micelles [J].

Cui, Can ;

Xue, Ya-Nan ;

Wu, Ming ;

Zhang, Yang ;

Yu, Ping ;

Liu, Lei ;

Zhuo, Ren-Xi ;

Huang, Shi-Wen .

BIOMATERIALS, 2013, 34 (15) :3858-3869

[3] Nanoparticle therapeutics: an emerging treatment modality for cancer [J].

Davis, Mark E. ;

Chen, Zhuo ;

Shin, Dong M. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782

[4] A facile strategy to generate polymeric nanoparticles for synergistic chemo-photodynamic therapy [J].

Deng, Xin ;

Liang, Yan ;

Peng, Xinyu ;

Su, Ting ;

Luo, Song ;

Cao, Jun ;

Gu, Zhongwei ;

He, Bin .

CHEMICAL COMMUNICATIONS, 2015, 51 (20) :4271-4274

[5] Self-Assembling Doxorubicin-Tocopherol Succinate Prodrug as a New Drug Delivery System: Synthesis, Characterization, and in Vitro and in Vivo Anticancer Activity [J].

Duhem, Nicolas ;

Danhier, Fabienne ;

Pourcelle, Vincent ;

Schumers, Jean-Marc ;

Bertrand, Olivier ;

LeDuff, Cecile S. ;

Hoeppener, Stephanie ;

Schubert, Ulrich S. ;

Gohy, Jean-Francois ;

Marchand-Brynaert, Jacqueline ;

Preat, Veronique .

BIOCONJUGATE CHEMISTRY, 2014, 25 (01) :72-81

[6] Viral Mimicking Ternary Polyplexes: A Reduction-Controlled Hierarchical Unpacking Vector for Gene Delivery [J].

He, Yiyan ;

Nie, Yu ;

Cheng, Gang ;

Xie, Li ;

Shen, Youqing ;

Gu, Zhongwei .

ADVANCED MATERIALS, 2014, 26 (10) :1534-1540

[7] The development of a gene vector electrostatically assembled with a polysaccharide capsule [J].

Kurosaki, Tomoaki ;

Kitahara, Takashi ;

Kawakami, Shigeru ;

Nishida, Koyo ;

Nakamura, Junzo ;

Teshima, Mugen ;

Nakagawa, Hiroo ;

Kodama, Yukinobu ;

To, Hideto ;

Sasaki, Hitoshi .

BIOMATERIALS, 2009, 30 (26) :4427-4434

[8] Polymeric micelles with π-π conjugated cinnamic acid as lipophilic moieties for doxorubicin delivery [J].

Lai, Yusi ;

Lei, Ying ;

Xu, Xianghui ;

Li, Yuanlin ;

He, Bin ;

Gu, Zhongwei .

JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (34) :4289-4296

[9] Enzyme-Sensitive and Amphiphilic PEGylated Dendrimer-Paclitaxel Prodrug-Based Nanoparticles for Enhanced Stability and Anticancer Efficacy [J].

Li, Ning ;

Cai, Hao ;

Jiang, Lei ;

Hu, Jiani ;

Bains, Ashika ;

Hu, Jesse ;

Gong, Qiyong ;

Luo, Kui ;

Gu, Zhongwei .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (08) :6865-6877

[10] Carrier-free, functionalized drug nanoparticles for targeted drug delivery [J].

Li, Wei ;

Yang, Yinlong ;

Wang, Chao ;

Liu, Zhuang ;

Zhang, Xiujuan ;

An, Feifei ;

Diao, Xiaojun ;

Hao, Xiaojun ;

Zhang, Xiaohong .

CHEMICAL COMMUNICATIONS, 2012, 48 (65) :8120-8122

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