Dermoscopy, reflectance confocal microscopy and histopathology of an amelanotic melanoma from an individual heterozygous for MC1R and tyrosinase variant alleles

被引：14
作者：
Curchin, Claudia [1 ,2 ]
Wurm, Elisabeth [2 ]
Jagirdar, Kasturee [3 ]
Sturm, Richard [3 ]
Soyer, Peter [1 ,2 ]
机构：
[1] Princess Alexandra Hosp, Dept Dermatol, Brisbane, Qld 4102, Australia
[2] Univ Queensland, Sch Med, Dermatol Res Ctr, Brisbane, Qld, Australia
[3] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
来源：
AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2012年 / 53卷 / 04期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
160W; amelanotic melanoma; melanocortin-1-receptor; nodular melanoma; red hair colour variant; reflectance confocal microscopy; rs1126809; tyrosinase; SCANNING LASER MICROSCOPY; MALIGNANT-MELANOMA; CUTANEOUS MELANOMA; FEATURES; SKIN; PHENOTYPE; RISK; METAANALYSIS; ASSOCIATION; RECEPTOR;
D O I：
10.1111/j.1440-0960.2012.00882.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We present a case of an amelanotic nodular melanoma occurring in a 26-year-old woman who carried a heterozygous (melancortin-1-receptor) MC1R 160R/W and tyrosinase (TYR) 402R/Q genotype and had a dark hair phenotype. We present dermoscopic, reflectance confocal microscopy (RCM) and histopathological images of the melanoma. We discuss the relationship between MC1R red hair colour (RHC) variants, TYR variants, phenotype and melanoma development. We also discuss the merits of RCM as an additional diagnostic aid for equivocal melanocytic lesions.
引用
收藏
页码：291 / 294
页数：4
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