Liver fibrosis with hypereosinophilia causing transient abnormal myelopoiesis

被引：7

作者：

Minakata, Shunsuke ^{[1
]}

Sakata, Naoki ^{[1
]}

Wada, Norihisa ^{[1
]}

Konishi, Yuhei ^{[1
]}

Marutani, Satoshi ^{[1
]}

Enya, Takuji ^{[1
]}

Nakagawa, Hidenori ^{[2
]}

Wada, Hiroshi ^{[2
]}

Takemura, Tsukasa ^{[1
]}

机构：

[1] Kindai Univ, Dept Pediat, Fac Med, Osaka, Japan

[2] Yodogawa Christians Hosp, Dept Pediat, Osaka, Japan

来源：

PEDIATRICS INTERNATIONAL | 2016年 / 58卷 / 11期

关键词：

eosinophilia; liver fibrosis; low-dose cytosine arabinoside; transient abnormal myelopoiesis; DOWN-SYNDROME; ONCOLOGY-GROUP; LEUKEMIA;

D O I：

10.1111/ped.13093

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Transient abnormal myelopoesis is mostly self-resolving and has a good prognosis, but some patients subsequently die of liver fibrosis. We report the case of an infant with Down syndrome who developed life-threatening liver fibrosis at the same time as the blasts were about to disappear. This patient also had a marked increase in eosinophils, which were possibly harboring a GATA1 mutation and were expressing a high level of platelet-derived growth factor-B mRNA; these may have been involved in the development of liver fibrosis. Low-dose cytosine arabinoside therapy effectively treated both hypereosinophilia and liver fibrosis.

引用

页码：1222 / 1225

页数：4

共 9 条

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