The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade

被引：45

作者：

Schurich, Anna ^{[1
]}

Raine, Charles ^{[2
]}

Morris, Vanessa ^{[2
]}

Ciurtin, Coziana ^{[2
]}

机构：

[1] UCL, Div Infect & Immun, London, England

[2] Univ Coll London Hosp NHS Trust, Dept Rheumatol, 3rd Floor Cent,250 Euston Rd, London NW1 2PG, England

来源：

RHEUMATOLOGY | 2018年 / 57卷 / 02期

关键词：

IL-12/23; blockade; psoriatic arthritis; psoriasis; ustekinumab; briakinumab; IL-12 related immunodeficiency; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; ACTIVE PSORIATIC-ARTHRITIS; CROHNS-DISEASE; DOUBLE-BLIND; I IFN; AUTOIMMUNE INFLAMMATION; EXPERIMENTAL COLITIS; RECEPTOR DEFICIENCY; MEMORY DEVELOPMENT; RANDOMIZED-TRIAL;

D O I：

10.1093/rheumatology/kex186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.

引用

页码：246 / 254

页数：9

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