The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade

被引：45
作者：
Schurich, Anna [1 ]
Raine, Charles [2 ]
Morris, Vanessa [2 ]
Ciurtin, Coziana [2 ]
机构：
[1] UCL, Div Infect & Immun, London, England
[2] Univ Coll London Hosp NHS Trust, Dept Rheumatol, 3rd Floor Cent,250 Euston Rd, London NW1 2PG, England
来源：
RHEUMATOLOGY | 2018年 / 57卷 / 02期
关键词：
IL-12/23; blockade; psoriatic arthritis; psoriasis; ustekinumab; briakinumab; IL-12 related immunodeficiency; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; ACTIVE PSORIATIC-ARTHRITIS; CROHNS-DISEASE; DOUBLE-BLIND; I IFN; AUTOIMMUNE INFLAMMATION; EXPERIMENTAL COLITIS; RECEPTOR DEFICIENCY; MEMORY DEVELOPMENT; RANDOMIZED-TRIAL;
D O I：
10.1093/rheumatology/kex186
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
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收藏
页码：246 / 254
页数：9
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