Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes

被引：26

作者：

Jeong, Min-Ho ^{[2
,3
]}

Seo, Min Jeong ^{[3
,4
]}

Park, Jeong Uck ^{[3
]}

Kang, Byoung Won ^{[3
]}

Kim, Kyoung-Sook ^{[3
]}

Lee, Jae Yun ^{[5
]}

Kim, Gi-Young ^{[6
]}

Kim, Jung-In ^{[7
]}

Choi, Yung Hyun ^{[8
]}

Kim, Kwang Hyuk ^{[1
]}

Jeong, Yong Kee ^{[2
,3
]}

机构：

[1] Kosin Univ, Coll Med, Dept Microbiol, Pusan 602708, South Korea

[2] Dong A Univ, Coll Med, Dept Microbiol, Pusan 602714, South Korea

[3] Dong A Univ, Medi Farm Ind Res Ctr, Pusan 604714, South Korea

[4] Dong A Univ, Dept Biotechnol, Pusan 604714, South Korea

[5] Cheongweon Ind Farm, Gimhae 621747, South Korea

[6] Jeju Natl Univ, Dept Marine Life Sci, Immunobiol Lab, Cheju 690756, South Korea

[7] Inje Univ, Sch Food & Life Sci, Gimhae 621749, South Korea

[8] Dong Eui Univ, Coll Oriental Med, Dept Biochem, Pusan 614050, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2012年 / 22卷 / 08期

关键词：

Cordycepin; Cordyceps militaris; IL-4; IL-10; IL-12; INTERFERON-GAMMA; 3'-DEOXYADENOSINE; INHIBITION; CELLS;

D O I：

10.4014/jmb.1203.03039

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cordycepin was purified from a mushroom, Cordyceps millions, and its effect on Th1 and Th2 cytokines was examined. The level of cytokine induction in mouse splenocytes was estimated after co-inoculation of purified cordycepin and LPS. When 5 mu g/ml of purified cordycepin was exposed to mouse splenocytes for 72 h, the level of a Th1 cytokine IL-12 increased by 2.9-fold. The addition of the purified cordycepin to splenocytes also increased the level of Th2 cytokines, IL-4 and IL-10, by 1.9- and 1.8-fold, respectively. Therefore, cordycepin increases the cytokine levels and may contribute to the up-regulation of cellular and humoral immunity.

引用

页码：1161 / 1164

页数：4

共 50 条

[31] An update on human Th1 and Th2 cells
Romagnani, S
Parronchi, P
DElios, MM
Romagnani, P
Annunziato, F
Piccinni, MP
Manetti, R
Sampognaro, S
Mavilia, C
DeCarli, M
Maggi, E
DelPrete, GF
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, 113 (1-3) : 153 - 156
[32] Differential TH1/TH2 Chemokine Expression in Interstitial Pneumonia
Honda, Toyohiro
Imaizumi, Kazuyoshi
Yokoi, Toyoharu
Hashimoto, Naozumi
Hashimoto, Izumi
Kawabe, Tsutomu
Matsuo, Masaki
Iwano, Shingo
Shimokata, Kaoru
Hasegawa, Yoshinori
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2010, 339 (01) : 41 - 48
[33] Chondrocytes from Osteoarthritis Patients Adopt Distinct Phenotypes in Response to Central TH1/TH2/TH17 Cytokines
Pemmari, Antti
Leppanen, Tiina
Hamalainen, Mari
Moilanen, Teemu
Moilanen, Eeva
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (17)
[34] Circulating Th1, Th2, and Th17 Levels in Hypertensive Patients
Ji, Qingwei
Cheng, Guojie
Ma, Ning
Huang, Ying
Lin, Yingzhong
Zhou, Qi
Que, Bin
Dong, Jianzeng
Zhou, Yujie
Nie, Shaoping
DISEASE MARKERS, 2017, 2017
[35] Effect of doxorubicin on cytokine production by lymphocytes and the Th1/Th2 balance
Santos, R. V. T.
Caperuto, E. C.
de Mello, M. T.
Costa Rosa, L. F. B. P.
BIOMEDICINE & PHARMACOTHERAPY, 2010, 64 (08) : 579 - 581
[36] Cocaine Use Disorder Is Associated With Changes in Th1/Th2/Th17 Cytokines and Lymphocytes Subsets
Zaparte, Aline
Schuch, Jaqueline B.
Viola, Thiago W.
Baptista, Talita A. S.
Beidacki, Amanda Stephanie
do Prado, Carine H.
Sanvicente-Vieira, Breno
Bauer, Moises E.
Grassi-Oliveira, Rodrigo
FRONTIERS IN IMMUNOLOGY, 2019, 10
[37] Divergent regulation of the murine CC chemokine C10 by Th1 and Th2 cytokines
Orlofsky, A
Wu, YQ
Prystowsky, MB
CYTOKINE, 2000, 12 (03) : 220 - 228
[38] Mangiferin Attenuates Th1/Th2 Cytokine Imbalance in an Ovalbumin-Induced Asthmatic Mouse Model
Guo, Hong-Wei
Yun, Chen-Xia
Hou, Guang-Han
Du, Jun
Huang, Xin
Lu, Yi
Keller, Evan T.
Zhang, Jian
Deng, Jia-Gang
PLOS ONE, 2014, 9 (06):
[39] The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications
Waskiel-Burnat, Anna
Osinska, Marta
Salinska, Anna
Blicharz, Leszek
Goldust, Mohamad
Olszewska, Malgorzata
Rudnicka, Lidia
CELLS, 2021, 10 (12)
[40] Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption
Cozen, W
Diaz-Sanchez, D
Gauderman, WJ
Zadnick, J
Cockburn, MG
Gill, PS
Masood, R
Hamilton, AS
Jyrala, M
Mack, TM
JOURNAL OF CLINICAL IMMUNOLOGY, 2004, 24 (06) : 617 - 622

← 1 2 3 4 5 →