Polymer Brushes Containing Sulfonated Sugar Repeat Units: Synthesis, Charaderization, and In Vitro Testing of Blood Coagulation Activation

被引：33

作者：

Ayres, N. ^{[1
]}

Holt, D. J. ^{[2
]}

Jones, C. F. ^{[2
]}

Corum, L. E. ^{[2
]}

Grainger, D. W. ^{[1
,2
]}

机构：

[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Biomed Engn, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2008年 / 46卷 / 23期

关键词：

atom transfer radical polymerization (ATRP); biocompatibility; biomaterials; biomimetic; blood; coagulation; films; heparin; in vitro; polymer brushes; sugars; sulfonated; surfaces;

D O I：

10.1002/pola.23075

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new polymer brush chemistry containing sulfonated carbohydrate repeat units has been synthesized from silicon substrates using ATRP methods and characterized both in bulk and using surface analysis. The polymer brush was designed to act as a mimic for the naturally occurring sulfonated glycosaminoglycan, heparin, commonly used for modifying blood-contacting surfaces both in vitro and in vivo. Surface analysis showed conversion of brush saccharide precursor chemistry to the desired sulfonated polymer product. The sulfonated polymer brush surface was further analyzed using three conventional in vitro tests for blood compatibility-plasma recalcification times, complement activation, and thrombin generation. The sulfonated polymer brush films on silicon oxide wafers exhibited better assay performance in these blood component assays than the unsulfonated sugar functionalized polymer brush in all tests performed. (C) 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7713-7724, 2008

引用

页码：7713 / 7724

页数：12

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