Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

被引：21

作者：

De Anda-Flores, Yubia ^{[1
]}

Carvajal-Millan, Elizabeth ^{[1
]}

Campa-Mada, Alma ^{[1
]}

Lizardi-Mendoza, Jaime ^{[1
]}

Rascon-Chu, Agustin ^{[2
]}

Tanori-Cordova, Judith ^{[3
]}

Martinez-Lopez, Ana Luisa ^{[4
]}

机构：

[1] Res Ctr Food & Dev CIAD AC, Biopolymers CTAOA, Carretera Gustavo Enrique Astiazaran Rosas 46, Hermosillo 83304, Mexico

[2] Res Ctr Food & Dev CIAD AC, Biotechnol CTAOV, Carretera Gustavo Enrique Astiazaran Rosas 46, Hermosillo 83304, Mexico

[3] Univ Sonora, Dept Polymers & Mat Res, Hermosillo 83000, Mexico

[4] Univ Navarra, Dept Chem & Pharmaceut Technol, NANO VAC Res Grp, Pamplona 31008, Spain

来源：

POLYSACCHARIDES | 2021年 / 2卷 / 03期

关键词：

nanoparticles; polysaccharide; drug delivery; colon; ORAL INSULIN DELIVERY; CHITOSAN NANOPARTICLES; IN-VITRO; ALGINATE NANOPARTICLES; MUCOADHESIVE; HYDROGELS; PEPTIDE; SURFACE; DESIGN; SIZE;

D O I：

10.3390/polysaccharides2030038

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.

引用

页码：626 / 647

页数：22

共 140 条

[111] Advances in micro and nano-encapsulation of bioactive compounds using biopolymer and lipid-based transporters [J].