Improved Beam Angle Arrangement in Intensity Modulated Proton Therapy Treatment Planning for Localized Prostate Cancer

被引:19
作者
Cao, Wenhua [1 ]
Lim, Gino J. [1 ]
Li, Yupeng [2 ]
Zhu, X. Ronald [3 ]
Zhang, Xiaodong [3 ]
机构
[1] Univ Houston, Dept Ind Engn, Houston, TX 77204 USA
[2] Appl Res Varian Med Syst, Palo Alto, CA 94304 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA
关键词
IMPT; treatment planning; beam angle optimization; prostate cancer; RANGE VERIFICATION; TREATMENT UNCERTAINTIES; CONFORMAL RADIOTHERAPY; ROBUST OPTIMIZATION; RADIATION-THERAPY; SENSITIVITY; QUALITY; IMPACT; IMRT;
D O I
10.3390/cancers7020574
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: This study investigates potential gains of an improved beam angle arrangement compared to a conventional fixed gantry setup in intensity modulated proton therapy (IMPT) treatment for localized prostate cancer patients based on a proof of principle study. Materials and Methods: Three patients with localized prostate cancer retrospectively selected from our institution were studied. For each patient, IMPT plans were designed using two, three and four beam angles, respectively, obtained from a beam angle optimization algorithm. Those plans were then compared with ones using two lateral parallel-opposed beams according to the conventional planning protocol for localized prostate cancer adopted at our institution. Results: IMPT plans with two optimized angles achieved significant improvements in rectum sparing and moderate improvements in bladder sparing against those with two lateral angles. Plans with three optimized angles further improved rectum sparing significantly over those two-angle plans, whereas four-angle plans found no advantage over three-angle plans. A possible three-beam class solution for localized prostate patients was suggested and demonstrated with preserved dosimetric benefits because individually optimized three-angle solutions were found sharing a very similar pattern. Conclusions: This study has demonstrated the potential of using an improved beam angle arrangement to better exploit the theoretical dosimetric benefits of proton therapy and provided insights of selecting quality beam angles for localized prostate cancer treatment.
引用
收藏
页码:574 / 584
页数:11
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