Regulatory Potential of the RNA Processing Machinery: Implications for Human Disease

被引：30

作者：

Carey, Kirstyn T. ^{[1
]}

Wickramasinghe, Vihandha O. ^{[1
]}

机构：

[1] Peter MacCallum Canc Inst, RNA Biol & Canc Lab, Melbourne, Vic 3000, Australia

来源：

TRENDS IN GENETICS | 2018年 / 34卷 / 04期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

DNA-DAMAGE RESPONSE; MESSENGER-RNA; SPLICING FACTOR; REPEAT EXPANSION; EXPORT PATHWAY; INCREASED EXPRESSION; RECURRENT MUTATIONS; R-LOOPS; PROTEIN; TRANSCRIPTION;

D O I：

10.1016/j.tig.2017.12.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Splicing and nuclear export of mRNA are critical steps in the gene expression pathway. While RNA processing factors can perform general, essential functions for intron removal and bulk export of mRNA, emerging evidence highlights that the core RNA splicing and export machineries also display regulatory potential. Here, we discuss recent insights into how this regulatory potential can selectively alter gene expression and regulate important biological processes. We also highlight the participation of RNA processing pathways in the cellular response to DNA damage at multiple levels. These findings have important implications for the contribution of selective mRNA processing and export to the development of human cancers and neurodegenerative disorders.

引用

页码：279 / 290

页数：12

共 99 条

[1] A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response [J].

Adamson, Britt ;

Smogorzewska, Agata ;

Sigoillot, Frederic D. ;

King, Randall W. ;

Elledge, Stephen J. .

NATURE CELL BIOLOGY, 2012, 14 (03) :318-+

[2] An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth [J].

Adler, Adam S. ;

McCleland, Mark L. ;

Yee, Sharon ;

Yaylaoglu, Murat ;

Hussain, Sofia ;

Cosino, Ely ;

Quinones, Gabriel ;

Modrusan, Zora ;

Seshagiri, Somasekar ;

Torres, Eric ;

Chopra, Vivek S. ;

Haley, Benjamin ;

Zhang, Zemin ;

Blackwood, Elizabeth M. ;

Singh, Mallika ;

Junttila, Melissa ;

Stephan, Jean-Philippe ;

Liu, Jinfeng ;

Pau, Gregoire ;

Fearon, Eric R. ;

Jiang, Zhaoshi ;

Firestein, Ron .

GENES & DEVELOPMENT, 2014, 28 (10) :1068-1084

[3] R Loops: From Transcription Byproducts to Threats to Genome Stability [J].

Aguilera, Andres ;

Garcia-Muse, Tatiana .

MOLECULAR CELL, 2012, 46 (02) :115-124

[4] Autosomal recessive mutations in THOC6 cause intellectual disability: syndrome delineation requiring forward and reverse phenotyping [J].

Amos, J. S. ;

Huang, L. ;

Thevenon, J. ;

Kariminedjad, A. ;

Beaulieu, C. L. ;

Masurel-Paulet, A. ;

Najmabadi, H. ;

Fattahi, Z. ;

Beheshtian, M. ;

Tonekaboni, S. H. ;

Tang, S. ;

Helbig, K. L. ;

Alcaraz, W. ;

Riviere, J. -B. ;

Faivre, L. ;

Innes, A. M. ;

Lebel, R. R. ;

Boycott, K. M. .

CLINICAL GENETICS, 2017, 91 (01) :92-99

[5] ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43 [J].

Arnold, Eveline S. ;

Ling, Shuo-Chien ;

Huelga, Stephanie C. ;

Lagier-Tourenne, Clotilde ;

Polymenidou, Magdalini ;

Ditsworth, Dara ;

Kordasiewicz, Holly B. ;

McAlonis-Downes, Melissa ;

Platoshyn, Oleksandr ;

Parone, Philippe A. ;

Da Cruz, Sandrine ;

Clutario, Kevin M. ;

Swing, Debbie ;

Tessarollo, Lino ;

Marsala, Martin ;

Shaw, Christopher E. ;

Yeo, Gene W. ;

Cleveland, Don W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) :E736-E745

[6] Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin [J].

Assouline, Sarit ;

Culjkovic, Biljana ;

Cocolakis, Eftihia ;

Rousseau, Caroline ;

Beslu, Nathalie ;

Amri, Abdellatif ;

Caplan, Stephen ;

Leber, Brian ;

Roy, Denis-Claude ;

Miller, Wilson H., Jr. ;

Borden, Katherine L. B. .

BLOOD, 2009, 114 (02) :257-260

[7] Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response [J].

Beli, Petra ;

Lukashchuk, Natalia ;

Wagner, Sebastian A. ;

Weinert, Brian T. ;

Olsen, Jesper V. ;

Baskcomb, Linda ;

Mann, Matthias ;

Jackson, Stephen P. ;

Choudhary, Chunaram .

MOLECULAR CELL, 2012, 46 (02) :212-225

[8] The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes [J].

Blazek, Dalibor ;

Kohoutek, Jiri ;

Bartholomeeusen, Koen ;

Johansen, Eric ;

Hulinkova, Petra ;

Luo, Zeping ;

Cimermancic, Peter ;

Ule, Jernej ;

Peterlin, B. Matija .

GENES & DEVELOPMENT, 2011, 25 (20) :2158-2172

[9] DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal [J].

Britton, Sebastien ;

Dernoncourt, Emma ;

Delteil, Christine ;

Froment, Carine ;

Schiltz, Odile ;

Salles, Bernard ;

Frit, Philippe ;

Calsou, Patrick .

NUCLEIC ACIDS RESEARCH, 2014, 42 (14) :9047-9062

[10] Temporal and Tissue Specific Regulation of RP-Associated Splicing Factor Genes PRPF3, PRPF31 and PRPC8-Implications in the Pathogenesis of RP [J].

Cao, Huibi ;

Wu, Jing ;

Lam, Simon ;

Duan, Rongqi ;

Newnham, Catherine ;

Molday, Robert S. ;

Graziotto, John J. ;

Pierce, Eric A. ;

Hu, Jim .

PLOS ONE, 2011, 6 (01)

← 1 2 3 4 5 6 7 8 9 10 →