Myoclonus associated with high-dose parenteral methadone

被引：7

作者：

Ito, Shiho ^{[2
]}

Liao, Solomon ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Med, Orange, CA 92868 USA

[2] VITAS Innovat Hosp Care, Orange, CA USA

来源：

JOURNAL OF PALLIATIVE MEDICINE | 2008年 / 11卷 / 06期

关键词：

D O I：

10.1089/jpm.2008.0040

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Methadone is generally believed to be devoid of neuroexcitatory properties, and its use is increasing. This paper reports two cases of myoclonus with high-dose parenteral methadone in patients with cancer under hospice care. This side effect may be dose related and/or due to the parenteral route of administration. Reduction of the dose and change of route was sufficient to eliminate the myoclonus while maintaining an adequate pain control. Possible mechanisms for methadone causing myoclonus include a redistribution of receptor saturation in the N-methyl-D-aspartate (NMDA) and delta receptors. Ketamine may be an option for patients with intractable pain who develop methadone-induced myoclonus.

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收藏

页码：838 / 841

页数：4

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