Flexible substrata for the detection of cellular traction forces

被引：202

作者：

Beningo, KA ^{[1
]}

Wang, YL ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Physiol, Worcester, MA 01605 USA

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0962-8924(01)02205-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

By modulating adhesion signaling and cytoskeletal organization, mechanical forces play an important role in various cellular functions, from propelling cell migration to mediating communication between cells. Recent developments have resulted in several new approaches for the detection, analysis and visualization of mechanical forces generated by cultured cells. Combining these methods with other approaches, such as green-fluorescent protein (GFP) imaging and gene manipulation, proves to be particularly powerful for analyzing the interplay between extracellular physical forces and intracellular chemical events.

引用

页码：79 / 84

页数：6

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