Wnt signaling in myogenesis

被引：319
作者：
von Maltzahn, Julia [1 ]
Chang, Natasha C. [1 ]
Bentzinger, C. Florian [1 ]
Rudnicki, Michael A. [1 ,2 ]
机构：
[1] Ottawa Hosp Res Inst, Sprott Ctr Stem Cell Res, Ottawa, ON, Canada
[2] Ottawa Hosp Res Inst, Regenerat Med Program, Ottawa, ON K1H 8L6, Canada
来源：
TRENDS IN CELL BIOLOGY | 2012年 / 22卷 / 11期
基金：
瑞士国家科学基金会; 加拿大健康研究院; 美国国家卫生研究院;
关键词：
Wnt; Frizzled; myogenesis; skeletal muscle; satellite cell; myofiber; SKELETAL-MUSCLE REGENERATION; SATELLITE STEM-CELLS; BETA-CATENIN; WNT/BETA-CATENIN; PARAXIAL MESODERM; ADULT MYOGENESIS; PATHWAY; EXPRESSION; PROTEINS; DIFFERENTIATION;
D O I：
10.1016/j.tcb.2012.07.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of Wnt signaling can lead to severe developmental defects and perturbation of muscle homeostasis. Recent work has revealed novel roles for the non-canonical planar cell polarity (PCP) and AKT/mTOR pathways in mediating the effects of Wnt on skeletal muscle. In this review, we discuss the role of Wnt signaling in myogenesis and in regulating the homeostasis of adult muscle.
引用
收藏
页码：602 / 609
页数：8
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