Improvement of aminolevulinic acid (ALA)-mediated photodynamic diagnosis using n-propyl gallate

被引：9

作者：

Hirano, Tomohisa ^{[1
]}

Hagiya, Yuichiro ^{[1
]}

Fukuhara, Hideo ^{[2
]}

Inoue, Keiji ^{[2
]}

Shuin, Taro ^{[2
]}

Matsumoto, Kentaro ^{[1
]}

Inoue, Katsushi ^{[3
]}

Tanaka, Tohru ^{[3
]}

Okura, Ichiro ^{[1
]}

Ogura, Shun-ichiro ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] Kochi Med Sch, Dept Urol, Nankoku, Kochi 7838505, Japan

[3] SBI Pharmaceut Co Ltd, Minato Ku, Tokyo 1066020, Japan

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2013年 / 10卷 / 01期

关键词：

Aminolevulinic acid; n-Propyl gallate; Protoporphyrin IX; Photodynamic diagnosis; ENDOGENOUS PROTOPORPHYRIN-IX; 5-AMINOLEVULINIC ACID; ORTHOTOPIC IMPLANTATION; METASTATIC VARIANTS; LOCALIZATION; THERAPY; PHOTOSENSITIZERS;

D O I：

10.1016/j.pdpdt.2012.06.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Photodynamic diagnosis (PDD) using aminolevulinic acid (ALA) is widely used in clinical fields. In PDD, protoporphyrin IX (PpIX) is generated from ALA in tumors, allowing the detection of the tumors by PpIX fluorescence. However, it is well known that PpIX is bleached by light irradiation (photobleaching) resulting in reduced PDD efficiency. In this study, n-propyl gallate (NPG) was investigated as an enhancer of PDD efficiency. Methods: Tumor cells were incubated with NPG after treatment with ALA, and reactive oxygen species and PpIX fluorescence were measured. Results: The antioxidant NPG suppressed the production of reactive oxygen species from light-irradiated porphyrins and ameliorated photobleaching of PpIX generated from ALA in vitro and in vivo. Conclusion: Incubation with NPG decreased the production of reactive oxygen species from PpIX and suppressed PpIX photobleaching. These results indicate that the antioxidant NPG may significantly improve PDD efficiency. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：28 / 32

页数：5

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