Antitumor effects of IDN5109 on head and neck squamous cell carcinoma

被引：1

作者：

Sano, D ^{[1
]}

Matsuda, H ^{[1
]}

Ishiguro, Y ^{[1
]}

Nishimura, G ^{[1
]}

Kawakami, M ^{[1
]}

Tsukuda, M ^{[1
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Biol & Funct Head & Neck, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

ONCOLOGY REPORTS | 2006年 / 15卷 / 02期

关键词：

IDN5109; taxane; head and neck squamous cell carcinoma; oral administration; anti-angiogenesis;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated the cellular response of IDN5 109 to head and neck squamous cell carcinoma (HNSCC), and compared the antitumor activity of IDN5109 with that of paclitaxel. This is the first demonstration of antitumor effects of IDN5109 on HNSCC. In in vitro experiments, IDN5109 showed anti proliferative effects against HNSCC cell lines. After treatment with IDN5109, Bcl-2 and Bcl-XL were down-regulated, Bax was upregulated, and caspase-3 was activated. After treatment with IDN5 109, concentrations of both VEGF and IL-8 in the culture supernatant of HNSCC cells decreased. In in vivo experiments, the oral administration of IDN5109 showed antitumor effects against HNSCC tumor xenografts. immunohistochemistry showed that IDN5109 inhibited tumor angiogenesis and induced apoptosis in HNSCC cells, producing a decreased blood vessel density and increased apoptosis index. On the basis of these results, IDN5109 is useful as a chemotherapeutic agent against HNSCC.

引用

页码：329 / 334

页数：6