Pyrrole-based partial peptidic mimic of neurotensin (8-13): Design and synthesis

被引：1
|
作者：
Zaidi, JH [1 ]
Naeem, F
Ambreen, N
Khan, KM
Pang, YP
Cusack, B
Richelson, E
Anwar, A
Voelter, W
机构：
[1] Quaid I Azam Univ, Dept Chem, Islamabad, Pakistan
[2] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan
[3] Mayo Fdn Med Educ & Res, Neurochem & Neuropharmacol Res, Jacksonville, FL 32224 USA
[4] Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany
来源：
LETTERS IN ORGANIC CHEMISTRY | 2006年 / 3卷 / 01期
关键词：
neurotensin; partial peptidic mimic; drug design; synthesis;
D O I：
10.2174/157017806774964530
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of pyrrole-based semipeptidic mimic of neuropeptide neurotensin (8-13) [NT(8-13)] is described. The design of this NT mimic is based on substitution of indole by a pyrrole nucleus.
引用
收藏
页码：21 / 24
页数：4
相关论文
共 50 条
  • [41] SOLID-PHASE SYNTHESIS OF PSI[CH(CN)NH] PSEUDOPEPTIDES - APPLICATION TO THE SYNTHESIS OF ANALOGS OF NEUROTENSIN [NT(8-13)]
    HERRANZ, R
    SUAREZGEA, ML
    GARCIALOPEZ, MT
    GONZALEZMUNIZ, R
    JOHANSEN, NL
    MADSEN, K
    THOGERSEN, H
    SUZDAK, P
    TETRAHEDRON LETTERS, 1993, 34 (51) : 8357 - 8360
  • [42] COMPARISON OF ANTINOCICEPTIVE AND HYPOTHERMIC EFFECTS OF INTRACEREBROVENTRICULAR NEUROTENSIN AND [D-TRP11]-NEUROTENSIN (8-13) IN MICE
    FURUTA, S
    SAKURADA, T
    SAKURADA, S
    KISARA, K
    MATSUI, M
    SASAKI, Y
    SUZUKI, K
    FOLIA PHARMACOLOGICA JAPONICA, 1984, 83 (06) : P55 - P56
  • [43] Synthesis and human neurotensin receptor binding activities of neurotensin(8-13) analogues containing position 8 α-azido-N-alkylated derivatives of ornithine, lysine, and homolysine
    Lundquist, JT
    Dix, TA
    JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (23) : 4914 - 4918
  • [44] Rhenium (Re) and technetium (Tc)-99M oxocomplexes of neurotensin(8-13)
    Chavatte, K.
    Wong, E.
    Fauconnier, T.K.
    Lu, L.
    Nguyen, T.
    Roe, D.
    Pollak, A.
    Eshima, D.
    Terriere, D.
    Mertens, J.
    Iterbeke, K.
    Tourwé, D.
    Thornback, J.
    Bossuyt, A.
    Journal of Labelled Compounds and Radiopharmaceuticals, 1999, 42 (05) : 415 - 421
  • [45] Rhenium (Re) and technetium (Tc)-99m oxocomplexes of neurotensin(8-13)
    Chavatte, K
    Wong, E
    Fauconnier, TK
    Lu, L
    Nguyen, T
    Roe, D
    Pollak, A
    Eshima, D
    Terriere, D
    Mertens, J
    Iterbeke, K
    Tourwé, D
    Thornback, J
    Bossuyt, A
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1999, 42 (05): : 415 - 421
  • [46] Modulation of CYP3A4 by the RGD- and Neurotensin (8-13)-analogues
    Georgiev, Kaloyan
    Radeva, Maya
    Balacheva, Anelia
    Michaylova, Sylvia
    Pajpanova, Tamara
    JOURNAL OF PEPTIDE SCIENCE, 2018, 24 : S133 - S133
  • [47] SYNTHESIS AND CHARACTERIZATION OF NEUROTENSIN ANALOGS FOR STRUCTURE ACTIVITY RELATIONSHIP STUDIES - ACETYL-NEUROTENSIN-(8-13) IS THE SHORTEST ANALOG WITH FULL BINDING AND PHARMACOLOGICAL ACTIVITIES
    GRANIER, C
    VANRIETSCHOTEN, J
    KITABGI, P
    POUSTIS, C
    FREYCHET, P
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 124 (01): : 117 - 124
  • [48] Utilization of ω-bromo-2-(S)-azido acids in the parallel synthesis of new neurotensin (8-13) analogues.
    Lundquist, JT
    Dix, TA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U233 - U233
  • [49] Design and preparation of pyrrole-based spin-polarized donors
    Nakazaki, J
    Chung, IG
    Matsushita, M
    Sugawara, T
    Watanabe, R
    Izuoka, A
    Kawada, Y
    JOURNAL OF MATERIALS CHEMISTRY, 2003, 13 (05) : 1011 - 1022
  • [50] Progress toward the synthesis of pyrrole-based alkaloid natural products
    Maki, Brooks
    Garcia, Alma
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
12345