Palladium-Catalyzed Coupling of Polyfluorinated Arenes with Heteroarenes via C-F/C-H Activation

被引：59
|
作者：
Yu, Daohong [1 ]
Lu, Long [1 ]
Shen, Qilong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 04期
基金：
中国国家自然科学基金;
关键词：
F BOND ACTIVATION; DIRECT ARYLATION; FLUORINE; PYRIDINES; AZOLES;
D O I：
10.1021/ol303567t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first palladium-catalyzed coupling of 2-pyrldyl-polyfluoroarenes and benzoxazole, thiazole, benzothiazole, benzoimidazole, oxazole or oxadiazole via a concurrent C-F/C-H activation is described. Initial mechanistic studies showed that C-F activation of perfluoroarene is likely the rate-limiting step of the catalytic cycle. This protocol provides a useful and operationally simple process to functionalized polyfluoroarenes.
引用
收藏
页码：940 / 943
页数：4
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