A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent

被引：265

作者：

Zhou, Zijian ^{[1
,2
]}

Huang, Dengtong ^{[1
,2
]}

Bao, Jianfeng ^{[3
,4
]}

Chen, Qiaoli ^{[1
,2
]}

Liu, Gang ^{[5
]}

Chen, Zhong ^{[3
,4
]}

Chen, Xiaoyuan ^{[5
,6
]}

Gao, Jinhao ^{[1
,2
,5
]}

机构：

[1] Xiamen Univ, Key Lab Chem Biol Fujian Prov, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Dept Elect Sci, Xiamen 361005, Peoples R China

[4] Xiamen Univ, Fujian Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China

[5] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China

[6] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 46期

基金：

美国国家科学基金会;

关键词：

T-1-T-2; dual-modal; synergistic enhancement; molecular imaging; accuracy; liver tumor; IRON-OXIDE NANOPARTICLES; MULTIFUNCTIONAL MAGNETIC NANOPARTICLES; SIZE-CONTROLLED SYNTHESIS; MRI CONTRAST; GADOLINIUM; T-1; RELAXATION; SURFACE;

D O I：

10.1002/adma.201203169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monodisperse Gd2O3-embedded iron oxide (GdIO) nanoparticles can simultaneously enhance the local magnetic field intensities of each other under an external magnetic field and result in synergistic enhancement of T-1 and T-2 effects. GdIO nanoparticles have the unique property to be both T-1 and T-2 contrast agents and can potentially lead to higher accuracy in cancer diagnosis, particularly liver tumors.

引用

页码：6223 / 6228

页数：6

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