Nonlinearities in Drug Release Process from Polymeric Microparticles: Long-Time-Scale Behaviour

被引：23

作者：

Bacaita, Elena Simona ^{[2
,3
]}

Bejinariu, Costica ^{[1
]}

Zoltan, Borsos ^{[4
]}

Peptu, Catalina ^{[2
]}

Andrei, Gabriela ^{[2
]}

Popa, Marcel ^{[2
]}

Magop, Daniela ^{[5
]}

Agop, Maricel ^{[3
,6
]}

机构：

[1] Gheorghe Asachi Tech Univ Iasi, Fac Mat Sci & Engn, Dept Mat Engn & Ind Secur, Iasi 700050, Romania

[2] Gheorghe Asachi Tech Univ Iasi, Fac Chem Engn & Environm Protect, Dept Nat & Synth Polymers, Iasi 700050, Romania

[3] Gheorghe Asachi Tech Univ Iasi, Fac Machine Mfg & Ind Management, Dept Phys, Iasi 700050, Romania

[4] Petr Gas Univ Ploiesti, Fac Letters & Sci, Dept Technol Informat Math & Phys, Ploiesti 100680, Romania

[5] Alexandru Ioan Cuza Univ, Dept Phys, Iasi 700506, Romania

[6] Univ Sci & Technol, Lasers Atoms & Mol Phys Lab, F-59655 Lille, France

来源：

JOURNAL OF APPLIED MATHEMATICS | 2012年

关键词：

IN-SILICO; MICROSPHERES; DISSOLUTION; DIFFUSION; SYSTEMS; MODEL;

D O I：

10.1155/2012/653720

中图分类号：

O29 [应用数学];

学科分类号：

070104 ;

摘要：

A theoretical model of the drug release process from polymeric microparticles (a particular type of polymer matrix), through dispersive fractal approximation of motion, is built. As a result, the drug release process takes place through cnoidal oscillations modes of a normalized concentration field. This indicates that, in the case of long-time-scale evolutions, the drug particles assemble in a lattice of nonlinear oscillators occur macroscopically, through variations of drug concentration. The model is validated by experimental results.

引用

页数：26

共 41 条

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