Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer

被引：112

作者：

Dandawate, Prasad R. ^{[2
]}

Vyas, Alok ^{[2
,3
]}

Ahmad, Aamir ^{[1
]}

Banerjee, Sanjeev ^{[1
]}

Deshpande, Jyoti ^{[3
]}

Swamy, K. Venkateswara ^{[3
]}

Jamadar, Abeda ^{[4
]}

Dumhe-Klaire, Anne Catherine ^{[4
]}

Padhye, Subhash ^{[1
,2
]}

Sarkar, Fazlul H.

机构：

[1] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Ctr, Dept Pathol,HWCRC 740, Detroit, MI 48201 USA

[2] Senior Coll Arts Sci & Commerce, MCE Soc Abeda Inamdar, Dept Chem, ISTRA, Pune 411001, Maharashtra, India

[3] Dr DY Patil Biotechnol & Bioinformat Inst, Pune 411044, Maharashtra, India

[4] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

PHARMACEUTICAL RESEARCH | 2012年 / 29卷 / 07期

关键词：

CDF; curcumin analog; CDF-beta-Cyclodextrin; pancreatic cancer; PHYSICOCHEMICAL CHARACTERIZATION; NANOPARTICLES; VITRO; STABILITY;

D O I：

10.1007/s11095-012-0700-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-beta-cyclodextrin inclusion complex (1:2) (CDFCD). The compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked. CDF-beta-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-beta-cyclodextrin in mice were 10 times higher than in serum, following intravenous administration of an aqueous CDF-beta-cyclodextrin preparation. Novel curcumin analog CDF preferentially accumulates in the pancreas, leading to its potent anticancer activity against pancreatic cancer cells. Synthesis of such CDF-beta-cyclodextrin self-assembly is an effective strategy to enhance its bioavailability and tissue distribution, warranting further evaluation for CDF delivery in clinical settings for treatment of human malignancies.

引用

页码：1775 / 1786

页数：12

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