Antioxidant Saffron Constituents Bind DNA and tRNA

被引：0
|
作者：
Kanakis, C. D. [1 ]
Tarantilis, P. A. [1 ]
Polissiou, M. G. [1 ]
Tajmir-Riahi, H. A.
机构：
[1] Agr Univ Athens, Dept Sci, Chem Lab, Athens 11855, Greece
来源：
III INTERNATIONAL SYMPOSIUM ON SAFFRON: FORTHCOMING CHALLENGES IN CULTIVATION, RESEARCH AND ECONOMICS | 2010年 / 850卷
关键词：
binding constant; binding sites; conformation; Crocus sativus L; FT-IR; UV-Visible; DIMETHYLCROCETIN; CROCETIN; CAROTENOIDS;
D O I：
暂无
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Crocetin (CRT) and dimethylcrocetin (DMCRT) are derived from saffron's carotenoids while safranal is the main component of its essential oil. The antioxidant activity of these compounds was tested by the DPPH antioxidant activity assay. Also the interactions of CRT, DMCRT and safranal with calf-thymus DNA and transfer RNA in aqueous solution at physiological conditions are reported. The structural analysis showed external binding to the major or minor groove and some degree of intercalation of saffron compounds to DNA and RNA. A partial B- to A-DNA transition occurs at high ligand concentration while tRNA remains in the A-family.
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页码：217 / 221
页数：5
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