Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study

被引：6

作者：

Tinca, Andreea Catalina ^{[1
,2
]}

Moraru, Raluca ^{[3
,4
]}

Cocuz, Iuliu Gabriel ^{[1
,2
]}

Sincu, Mihaela Cornelia ^{[1
,2
]}

Niculescu, Raluca ^{[1
,2
]}

Sabau, Adrian Horatiu ^{[1
,2
]}

Chiorean, Diana Maria ^{[1
,2
]}

Szoke, Andreea Raluca ^{[1
,2
]}

Morariu, Silviu-Horia ^{[5
,6
]}

Cotoi, Ovidiu Simion ^{[2
,7
]}

机构：

[1] Univ Med Pharm Sci & Technol George Emil Palade T, Doctoral Sch Med & Pharm, Targu Mures 540142, Romania

[2] Mures Clin Cty Hosp, Pathol Dept, Targu Mures 540011, Romania

[3] Mure Clin Cty Hosp, Dept Plast Surg, Targu Mures 540011, Romania

[4] Univ Med Pharm Sci & Technol George Emil Palade T, Anat Dept, Targu Mures 540142, Romania

[5] Univ Med Pharm Sci & Technol George Emil Palade T, Dermatol Dept, Targu Mures 540142, Romania

[6] Mures Clin Cty Hosp, Dept Dermatol & Venerol, Targu Mures 540011, Romania

[7] Univ Med Pharm Sci & Technol George Emil Palade T, Pathophysiol Dept, Targu Mures 540142, Romania

来源：

BIOMEDICINES | 2022年 / 10卷 / 10期

关键词：

melanoma; immunohistochemistry; BRAF; metastases; sentinel lymph nodes; LYMPH-NODE BIOPSY; UVEAL MELANOMA; METASTATIC MELANOMA; MALIGNANT-MELANOMA; SOX10; EXPRESSION; CLASSIFICATION; PROGNOSIS; DIAGNOSIS; PROTEIN; VISTA;

D O I：

10.3390/biomedicines10102500

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanoma is the most aggressive melanocytic tumor whose incidence is continuously increasing worldwide. Methods: We highlight the morphological, immunohistochemistry, and particularities of various melanoma types based on the cases diagnosed in our department from 2017 to 2021. Results: We present 100 melanoma cases and one capsular nevus case. The most common type was nodular melanoma. The immunohistochemistry markers used were SRY-box transcription factor 10 (SOX10), S100 protein, human melanoma black 45 (HMB45), and melanoma antigen recognized by T cells 1 (Melan-A). Uveal melanoma and conjunctival melanoma represent particular tumors with independent prognostic factors. Uveal melanoma requires assessment of macrophages, microvascularisation, and mitoses. Sentinel lymph node metastases are essential targets that provide staging tools. Conjunctival melanoma and capsular nevi are diagnostic pitfalls. Conclusion: Melanoma can appear in various forms, and sometimes the diagnosis might be unclear. Today, immunohistochemistry remains the most important tool in confirming the diagnosis and prognosis for this type of neoplasia.

引用

页数：17