Re-positive coronavirus disease 2019 PCR test: could it be a reinfection?

被引：46
作者：
Osman, A. A. [1 ]
Al Daajani, M. M. [2 ]
Alsahafi, A. J. [3 ]
机构：
[1] Umm Al Qura Univ, Fac Publ Hlth & Hlth Informat, Dept Hlth Educ & Promot, Mecca, Saudi Arabia
[2] Minist Hlth, Publ Hlth Agcy, Prevent Med & Publ Hlth, Riyadh, Saudi Arabia
[3] Jeddah Hlth Affairs, Dept Publ Hlth, Jeddah, Saudi Arabia
来源：
NEW MICROBES AND NEW INFECTIONS | 2020年 / 37卷
关键词：
Coronavirus disease 2019; CT scan; False-negative; Low viral load; RT-qPCR; Severe acute respiratory syndrome coronavirus 2; ACUTE RESPIRATORY SYNDROME; COVID-19; SARS-COV-2; RNA;
D O I：
10.1016/j.nmni.2020.100748
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The coronavirus disease 2019 (COVID-19) outbreak started in December 2019 and rapidly spread around the globe as a major health threat. Several reports on re-positive cases subsequent to discharge from hospitals caught our attention. We aimed to highlight RT-qPCR positivity re-detection after discharge from isolation, with special consideration of the possible reasons behind it. We found that re-positive RT-qPCR assays for severe acute respiratory syndrome coronavirus 2 after previous negative results might be attributed to false-negative laboratory results and prolonged viral shedding, rather than to re-infection. These findings are encouraging and should be validated in a larger cohort. (C) 2020 The Authors. Published by Elsevier Ltd.
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页数：6
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