Re-positive coronavirus disease 2019 PCR test: could it be a reinfection?

被引：46

作者：

Osman, A. A. ^{[1
]}

Al Daajani, M. M. ^{[2
]}

Alsahafi, A. J. ^{[3
]}

机构：

[1] Umm Al Qura Univ, Fac Publ Hlth & Hlth Informat, Dept Hlth Educ & Promot, Mecca, Saudi Arabia

[2] Minist Hlth, Publ Hlth Agcy, Prevent Med & Publ Hlth, Riyadh, Saudi Arabia

[3] Jeddah Hlth Affairs, Dept Publ Hlth, Jeddah, Saudi Arabia

来源：

NEW MICROBES AND NEW INFECTIONS | 2020年 / 37卷

关键词：

Coronavirus disease 2019; CT scan; False-negative; Low viral load; RT-qPCR; Severe acute respiratory syndrome coronavirus 2; ACUTE RESPIRATORY SYNDROME; COVID-19; SARS-COV-2; RNA;

D O I：

10.1016/j.nmni.2020.100748

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The coronavirus disease 2019 (COVID-19) outbreak started in December 2019 and rapidly spread around the globe as a major health threat. Several reports on re-positive cases subsequent to discharge from hospitals caught our attention. We aimed to highlight RT-qPCR positivity re-detection after discharge from isolation, with special consideration of the possible reasons behind it. We found that re-positive RT-qPCR assays for severe acute respiratory syndrome coronavirus 2 after previous negative results might be attributed to false-negative laboratory results and prolonged viral shedding, rather than to re-infection. These findings are encouraging and should be validated in a larger cohort. (C) 2020 The Authors. Published by Elsevier Ltd.

引用

页数：6

共 39 条

[1] Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance [J].

不详 .

PEDIATRIA I MEDYCYNA RODZINNA-PAEDIATRICS AND FAMILY MEDICINE, 2020, 16 (01) :9-26

[2]

[Anonymous], COR DIS COVID 19 PAN

[3] False-negative results of initial RT-PCR assays for COVID-19: A systematic review [J].

Arevalo-Rodriguez, Ingrid ;

Buitrago-Garcia, Diana ;

Simancas-Racines, Daniel ;

Zambrano-Achig, Paula ;

Del Campo, Rosa ;

Ciapponi, Agustin ;

Sued, Omar ;

Martinez-Garcia, Laura ;

Rutjes, Anne W. ;

Low, Nicola ;

Bossuyt, Patrick M. ;

Perez-Molina, Jose A. ;

Zamora, Javier .

PLOS ONE, 2020, 15 (12)

[4]

Bui TD, 2020, I S BIOMED IMAGING, P359, DOI [10.1109/isbi45749.2020.9098515, 10.1109/ISBI45749.2020.9098515]

[5] Assay Techniques and Test Development for COVID-19 Diagnosis [J].

Carter, Linda J. ;

Garner, Linda, V ;

Smoot, Jeffrey W. ;

Li, Yingzhu ;

Zhou, Qiongqiong ;

Saveson, Catherine J. ;

Sasso, Janet M. ;

Gregg, Anne C. ;

Soares, Divya J. ;

Beskid, Tiffany R. ;

Jervey, Susan R. ;

Liu, Cynthia .

ACS CENTRAL SCIENCE, 2020, 6 (05) :591-605

[6]

Centers for Disease Control and Prevention, 2020, COR DIS 2019 COVID 1

[7] Positive conversion of COVID-19 after two consecutive negative RT-PCR results: A role of low-dose CT [J].

Chae, Kum Ju ;

Jin, Gong Yong ;

Lee, Chang-Seop ;

Lee, Heung Bum ;

Lee, Ju-Hyung ;

Kwon, Keun-Sang .

EUROPEAN JOURNAL OF RADIOLOGY, 2020, 129

[8] Recurrence of positive SARS-CoV-2 RNA in COVID-19: A case report [J].

Chen, Dabiao ;

Xu, Wenxiong ;

Lei, Ziying ;

Huang, Zhanlian ;

Liu, Jing ;

Gao, Zhiliang ;

Peng, Liang .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 93 :297-299

[9] COVID-19 Disease With Positive Fecal and Negative Pharyngeal and Sputum Viral Tests [J].

Chen, Lijuan ;

Lou, Jianghua ;

Bai, Yan ;

Wang, Meiyun .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2020, 115 (05) :790-790

[10] Re-evaluation of retested nucleic acid-positive cases in recovered COVID-19 patients: Report from a designated transfer hospital in Chongqing, China [J].

Chen, Yan ;

Bai, Weizhi ;

Liu, Bin ;

Huang, Jian ;

Laurent, Irakoze ;

Chen, Feng ;

Deng, Wuquan ;

Xiao, Xiaoqiu .

JOURNAL OF INFECTION AND PUBLIC HEALTH, 2020, 13 (07) :932-934

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