Who binds wins: competition for PCNA rings out cell-cycle changes

被引：48
作者：
Cox, LS
机构：
[1] Dept. of Biochemistry, University of Oxford
来源：
TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 12期
关键词：
D O I：
10.1016/S0962-8924(97)01170-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
PCNA, proliferating cell nuclear antigen, is a pivotal protein in DNA replication, DNA repair and possibly cell-cycle control. The protein has a trimeric ring structure that might slide along duplex DNA and form a platform for association with a variety of proteins, in particular holding the DNA polymerases in close association with their template. This article reviews evidence suggesting that the activity of PCNA in replication and repair is coordinated within the cell cycle by cooperative and competitive interactions with an extensive network of enzymes and regulatory proteins.
引用
收藏
页码：493 / 498
页数：6
相关论文
共 60 条
[1]   MAMMALIAN DNA NUCLEOTIDE EXCISION-REPAIR RECONSTITUTED WITH PURIFIED PROTEIN-COMPONENTS [J].
ABOUSSEKHRA, A ;
BIGGERSTAFF, M ;
SHIVJI, MKK ;
VILPO, JA ;
MONCOLLIN, V ;
PODUST, VN ;
PROTIC, M ;
HUBSCHER, U ;
EGLY, JM ;
WOOD, RD .
CELL, 1995, 80 (06) :859-868
[2]   CLONING AND SEQUENCE OF THE HUMAN NUCLEAR-PROTEIN CYCLIN - HOMOLOGY WITH DNA-BINDING PROTEINS [J].
ALMENDRAL, JM ;
HUEBSCH, D ;
BLUNDELL, PA ;
MACDONALDBRAVO, H ;
BRAVO, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (06) :1575-1579
[3]  
AYYAGARI R, 1995, MOL CELL BIOL, V15, P4420
[4]   Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21(WAF1) [J].
Ball, KL ;
Lain, S ;
Fahraeus, R ;
Smythe, C ;
Lane, DP .
CURRENT BIOLOGY, 1997, 7 (01) :71-80
[5]  
BASERGA R, 1991, J CELL SCI, V98, P433
[6]   MOLECULAR-CLONING, STRUCTURE AND EXPRESSION OF THE YEAST PROLIFERATING CELL NUCLEAR ANTIGEN GENE [J].
BAUER, GA ;
BURGERS, PMJ .
NUCLEIC ACIDS RESEARCH, 1990, 18 (02) :261-265
[7]   CHANGES IN THE NUCLEAR-DISTRIBUTION OF CYCLIN (PCNA) BUT NOT ITS SYNTHESIS DEPEND ON DNA-REPLICATION [J].
BRAVO, R ;
MACDONALDBRAVO, H .
EMBO JOURNAL, 1985, 4 (03) :655-661
[8]   CYCLIN PCNA IS THE AUXILIARY PROTEIN OF DNA POLYMERASE-DELTA [J].
BRAVO, R ;
FRANK, R ;
BLUNDELL, PA ;
MACDONALDBRAVO, H .
NATURE, 1987, 326 (6112) :515-517
[9]   EXISTENCE OF 2 POPULATIONS OF CYCLIN PROLIFERATING CELL NUCLEAR ANTIGEN DURING THE CELL-CYCLE - ASSOCIATION WITH DNA-REPLICATION SITES [J].
BRAVO, R ;
MACDONALDBRAVO, H .
JOURNAL OF CELL BIOLOGY, 1987, 105 (04) :1549-1554
[10]  
BURGERS PMJ, 1991, J BIOL CHEM, V266, P22698
123456