HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes

被引：1

作者：

Kennedy, Alan ^{[1
]}

Petrasca, Andreea ^{[2
]}

Doherty, Derek G. ^{[2
]}

Hennessy, Martina ^{[1
]}

Spiers, J. Paul ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Pharmacol & Therapeut, Sch Med, Dublin, Ireland

[2] Trinity Coll Dublin, Dept Immunol, Sch Med, Dublin, Ireland

来源：

AIDS | 2014年 / 28卷 / 01期

关键词：

CELLS; PROTEIN; MONOCYTES; P38;

D O I：

10.1097/QAD.0000000000000043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 Tat exhibits clade-specific cytokine induction in monocytes. We investigated if Tat clades A-D can alter tumour necrosis factor (TNF)- and interferon (IFN)- production by total and V9V2 T cells in vitro. Tat clade B, but not C, augmented TNF- production by THP-1 cells. However, Tat clades A-D did not affect TNF- or IFN- production or secretion by resting or activated conventional and V9V2 T cells. Therefore, transactivation of cytokines by Tat is immune cell-specific.

引用

页码：131 / 136

页数：6