PALLADIUM-CATALYZED DIRECT ARYLATION AND ALKENYLATION OF 3-(INDOL-3-YL)PROPIONIC ACIDS THROUGH C-H BOND CLEAVAGE

被引：5

作者：

Takeda, Daisuke ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
,2
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] JST, ACTC, Kawaguchi, Saitama 3320012, Japan

来源：

HETEROCYCLES | 2014年 / 88卷 / 01期

关键词：

C-H Bond Cleavage; Arylation; Alkenylation; Indole; Palladium Catalyst; HETEROAROMATIC-COMPOUNDS; COMBINATORIAL SYNTHESIS; COUPLING REACTIONS; ROOM-TEMPERATURE; ARYL HALIDES; FUNCTIONALIZATION; INDOLES; CARBON; DISCOVERY; ALKYNES;

D O I：

10.3987/COM-13-S(S)13

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed direct arylation of 3-(indol-3-yl)propionic acids with aryl bromides proceeds through C H bond cleavages to give C2-arylated product in good yields. The C2-alkenylation of the substrates can also be performed smoothly under appropriate oxidative conditions.

引用

页码：275 / 286

页数：12

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