A new asymmetric synthesis of (+)-grandisol via a kinetic resolution.

被引：11
|
作者：
Hamon, DPG [1 ]
Tuck, KL [1 ]
机构：
[1] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 42期
关键词：
D O I：
10.1016/S0040-4039(99)01605-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.). (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7569 / 7572
页数：4
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