A new asymmetric synthesis of (+)-grandisol via a kinetic resolution.

被引：11

作者：

Hamon, DPG ^{[1
]}

Tuck, KL ^{[1
]}

机构：

[1] Univ Adelaide, Dept Chem, Adelaide, SA 5005, Australia

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(99)01605-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allylic alcohol is prepared in 4 steps from simple achiral materials and the resolved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl alkene. This alkene is converted to (+)-grandisol (95%e.e.). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7569 / 7572

页数：4

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