CO-Releasing Polymers Exert Antimicrobial Activity

被引：83

作者：

Diep Nguyen ^{[1
,2
]}

Thuy-Khanh Nguyen ^{[1
,2
]}

Rice, Scott A. ^{[3
,4
,5
]}

Boyer, Cyrille ^{[1
,2
]}

机构：

[1] Univ New S Wales, Australian Ctr Nanomed, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Sch Chem Engn, Ctr Adv Macromol Design, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Sch Biol Earth & Environm Sci, Ctr Marine Innovat, Sydney, NSW 2052, Australia

[4] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 639798, Singapore

[5] Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore

来源：

BIOMACROMOLECULES | 2015年 / 16卷 / 09期

基金：

澳大利亚研究理事会;

关键词：

CARBON-MONOXIDE; PSEUDOMONAS-AERUGINOSA; DRUG-DELIVERY; NANOPARTICLES; MOLECULES; RESPIRATION; INFECTIONS; BEARING; LIGHT;

D O I：

10.1021/acs.biomac.5b00716

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infectious diseases remain one of the leading causes of death worldwide despite the tremendous effort devoted to the design and development of antimicrobial agents. However, the decrease in the effectiveness of some antibiotics is often associated with the development of drug resistance by pathogen. This leads to an urgent need for the development of new therapeutic approaches that can overcome the development of drug resistance. Recent evidence suggests that the biological signaling molecule carbon monoxide (CO) presents remarkable antimicrobial properties. Herein, we report the design and synthesis of a new type of water-soluble CO-releasing polymer with antimicrobial activity against Pseudomonas aeruginosa that is highly efficient at preventing biofilm formation.

引用

页码：2776 / 2786

页数：11

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