Anti-cancer effect of Cassia auriculata leaf extract in vitro through cell cycle arrest and induction of apoptosis in human breast and larynx cancer cell lines

被引：50
|
作者：
Prasanna, R. [1 ]
Harish, C. C. [2 ]
Pichai, R. [1 ]
Sakthisekaran, D. [3 ]
Gunasekaran, P. [2 ]
机构：
[1] Presidency Coll, Dept Chem, Madras 600005, Tamil Nadu, India
[2] King Inst Prevent Med, Dept Virol, Madras 600032, Tamil Nadu, India
[3] Univ Madras, Dept Med Biochem, Madras, Tamil Nadu, India
来源：
CELL BIOLOGY INTERNATIONAL | 2009年 / 33卷 / 02期
关键词：
Cassia auriculata; MCF-7; Hep-2; Cell cycle; Apoptosis; Bax/Bcl-2; THYMOCYTE APOPTOSIS; MCF-7; CELLS; CARCINOMA; PROLIFERATION; GROWTH; PLANTS; DEATH; BCL-2;
D O I：
10.1016/j.cellbi.2008.10.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The in vitro anti-cancer effect of Cassia auriculata leaf extract (CALE) was evaluated in human breast adenocarcinoma MCF-7 and human larynx carcinoma Hep-2 cell lines. CALE preferentially inhibited the growth of both the cell lines in a dose-dependent manner with IC50 values of 400 and 500 mu g for MCF-7 and Hep-2 cells, respectively. The results showed the anti-cancer action is due to nuclear fragmentation and condensation, associated with the appearance of A(0) peak in cell cycle analysis that is indicative of apoptosis. In addition, CALE treated MCF-7 and Hep-2 cells had decreased expression of anti-apoptotic Bcl-2 protein and increased expression of pro-apoptotic Bax protein, eventually leading a decrease in the Bcl-2/Bax ratio. These results demonstrated that CALE inhibits the proliferation of MCF-7 and Hep-2 cells through induction of apoptosis, making CALE a candidate as new anti-cancer drug. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：127 / 134
页数：8
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