Carving a Niche for Antibacterial α-Defensins when Craving

被引：1
作者：
Foerster, Elisabeth G. [1 ]
Girardin, Stephen E. [1 ,2 ]
机构：
[1] Univ Toronto, Dept Immunol, Toronto, ON, Canada
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
来源：
CELL HOST & MICROBE | 2019年 / 25卷 / 05期
关键词：
ACTIVATION;
D O I：
10.1016/j.chom.2019.04.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this issue of Cell Host & Microbe, Liang et al. (2019) show that alpha-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an alpha-defensin regulator, which sustains alpha-defensin levels, loss of which increases lethality during bacterial infection.
引用
收藏
页码：632 / 634
页数：4
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