Neuroprotective Effects of Nannochloropsis oculata Against AAPH-induced Oxidative DNA Damage in HT22 Cells

被引：6

作者：

Kim, Kil-Nam ^{[1
]}

Cha, Seon-Heui ^{[2
,3
]}

Kim, Eun-A ^{[4
]}

Kang, Min-Cheol ^{[4
]}

Yang, Hye-Mi ^{[1
]}

Kim, Min-Joo ^{[1
]}

Yang, Hye-Young ^{[1
]}

Roh, Seong Woon ^{[1
]}

Jung, Won-Kyo ^{[5
]}

Heo, Soo-Jin ^{[6
]}

Kim, Daekyung ^{[1
]}

Jeon, You-Jin ^{[4
]}

Oda, Tatsuya ^{[7
]}

机构：

[1] Korea Basic Sci Inst, Marine Bio Res Team, Cheju 690140, South Korea

[2] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[4] Jeju Natl Univ, Sch Marine Biomed Sci, Cheju 690756, South Korea

[5] Chosun Univ, Dept Marine Life Sci, Kwangju 501759, South Korea

[6] Korea Inst Ocean Sci & Technol, Global Bioresources Res Ctr, Ansan 426744, South Korea

[7] Nagasaki Univ, Fac Fisheries, Div Biochem, Nagasaki 8528521, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACOLOGY | 2012年 / 8卷 / 06期

关键词：

Neuroprotection; water extract; Nannochloprosis oculata; oxidative stress; HT22; cells; MICROALGAE NAVICULA-INCERTA; ANTIOXIDANT ACTIVITIES; ENZYMATIC EXTRACTS; ISHIGE OKAMURAE; ECKLONIA-CAVA; STRESS; TOXICITY; ACID; INDUCTION; RELEVANCE;

D O I：

10.3923/ijp.2012.527.534

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Water extracts of Nannochloropsis oculata (WNO) were investigated to determine whether they exhibited neuroprotective effects against oxidative-stress-induced cell damage by 2,2'-Azobis (2-amidinopropane) dihydrochloride (AAPH) in murine hippocampus neuronal (HT22) cells. We observed that WNO exhibited scavenging effects on hydroxyl and alkyl radicals as well as on intracellular Reactive Oxygen Species (ROS). As a consequence, WNO reduced AAPH-induced cell death, the fraction of sub-G(1) cells and DNA damage in HT22 cells. The results of this study demonstrate that WNO could be used as an alternative to more toxic synthetic antioxidants as an additive in food, pharmaceutical and cosmetic preparations.

引用

页码：527 / 534

页数：8

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