Saponins from the bark of Nephelium maingayi

被引：44
作者：
Ito, A
Chai, HB
Kardono, LBS
Setowati, FM
Afriastini, JJ
Riswan, S
Farnsworth, NR
Cordell, GA
Pezzuto, JM
Swanson, SM
Kinghorn, AD [1 ]
机构：
[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
[3] Indonesian Inst Sci, Res Ctr Chem, Tangerang 15310, Indonesia
[4] Indonesian Inst Sci, Herbarium Bogoriense, Biol Res Ctr, Bogor 16122, Indonesia
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 02期
关键词：
D O I：
10.1021/np030389e
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Activity-guided fractionation of the bark of Nephelium maingayi, collected in Indonesia, led to the isolation of six new saponins (1-6). The aglycon of 4 was determined to be a new compound, 7alpha-methoxyerythrodiol, and those of 1-3 and of 5 and 6 were identified as erythrodiol and maniladiol (16beta-hydroxyamyrin), respectively. The structures of 1-6 were determined on the basis of spectral data interpretation, and the absolute configurations of their component monosaccharides were determined as their thiazolidine derivatives after acid hydrolysis. Of the isolates, only compounds I and 5 showed very weak cytotoxic activity against a panel of human tumor cell lines.
引用
收藏
页码：201 / 205
页数：5
相关论文
共 20 条
[1]   TRITERPENES OF GALLS OF PISTACIA-TEREBINTHUS - GALLS PRODUCED BY PEMPHIGUS-UTRICULARIUS [J].
CAPUTO, R ;
MANGONI, L ;
MONACO, P ;
PALUMBO, G .
PHYTOCHEMISTRY, 1975, 14 (03) :809-811
[2]   Comparative content of total polyphenols and dietary fiber in tropical fruits and persimmon [J].
Gorinstein, S ;
Zemser, M ;
Haruenkit, R ;
Chuthakorn, R ;
Grauer, F ;
Martin-Belloso, O ;
Trakhtenberg, S .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 1999, 10 (06) :367-371
[3]  
HARA S, 1987, CHEM PHARM BULL, V35, P501
[4]   The occurrence and characteristics of long chain polyprenols from leaves of Sapindaceae [J].
Jankowski, WJ ;
Chojnacki, T .
JOURNAL OF PLANT PHYSIOLOGY, 1995, 147 (3-4) :289-293
[5]   Novel strategies for the discovery of plant-derived anticancer agents [J].
Kinghorn, AD ;
Farnsworth, NR ;
Soejarto, DD ;
Cordell, GA ;
Pezzuto, JM ;
Udeani, GO ;
Wani, MC ;
Wall, ME ;
Navarro, HA ;
Kramer, RA ;
Menendez, AT ;
Fairchild, CR ;
Lane, KE ;
Forenza, S ;
Vyas, DM ;
Lam, KS ;
Shu, YZ .
PURE AND APPLIED CHEMISTRY, 1999, 71 (09) :1611-1618
[6]   An investigation of antioxidant capacity of fruits in Singapore markets [J].
Leong, LP ;
Shui, G .
FOOD CHEMISTRY, 2002, 76 (01) :69-75
[7]   CHEMISTRY OF THE ANNONACEAE .27. POLYOXYGENATED CYCLOHEXANE EPOXIDE DERIVATIVES FROM THE STEM BARK OF MONANTHOTAXIS-BUCHANANII [J].
LIANG, GY ;
GRAY, AI ;
THOMAS, DW ;
WATERMAN, PG .
PHYTOCHEMISTRY, 1988, 27 (12) :3857-3860
[8]  
LIKHITWITAYAWUI.K, 1996, J NAT PRODUCTS, V56, P30
[9]  
LOH CH, 1952, AGR RES, V3, P7
[10]   Novel bioactive phenanthrene derivatives from Domohinea perrieri [J].
Long, L ;
Lee, SK ;
Chai, HB ;
Rasoanaivo, P ;
Gao, Q ;
Navarro, H ;
Wall, ME ;
Wani, MC ;
Farnsworth, NR ;
Cordell, GA ;
Pezzuto, JM ;
Kinghorn, AD .
TETRAHEDRON, 1997, 53 (46) :15663-15670
12