Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma

被引:4
|
作者
Weiss, Bernhard G. [1 ]
Anczykowski, Mahalia Zoe [2 ]
Kueffer, Stefan [4 ]
Spiegel, Jennifer L. [1 ]
Bertlich, Mattis [1 ]
Canis, Martin [1 ]
Ihler, Friedrich [1 ,3 ]
Kitz, Julia [4 ]
Jakob, Mark [1 ]
机构
[1] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Otorhinolaryngol, Marchioninistr 15, D-81377 Munich, Germany
[2] Univ Med Ctr Gottingen, Dept Otorhinolaryngol Head & Neck Surg, Robert Koch Str 40, D-37075 Gottingen, Germany
[3] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, German Ctr Vertigo & Balance Disorders DSGZ, Marchioninistr 15, D-81377 Munich, Germany
[4] Univ Med Ctr Gottingen, Inst Pathol, Robert Koch Str 40, D-37075 Gottingen, Germany
关键词
Oropharyngeal squamous cell carcinoma; Oropharyngeal cancer; p16; Human papillomavirus (HPV); Prognosis; Head and neck squamous cell carcinomas (HNSCC); AMERICAN JOINT COMMITTEE; HUMAN-PAPILLOMAVIRUS TYPE-16; 8TH EDITION; NECK-CANCER; HEAD; RISK; P16; ASSOCIATION; EXPRESSION; SURVIVAL;
D O I
10.1007/s00405-020-06262-7
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Purpose p16 overexpression was considered as surrogate marker to identify human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCCs). Methods 102 patients with advanced stage OPSCCs treated primarily by transoral lasermicrosurgery were included. Prognostic associations of p16- and HPV-status were analyzed separately and combined. Results In contrast to p16, the HPV-status resulted in no significant survival discrepancies (5-year overall survival (OS) HPV-positive 64.9%, HPV-negative 78.7%). Combining both markers, p16-positive (p16-positive/HPV-positive, p16-positive/HPV-negative) and p16-negative/HPV-negative groups demonstrated comparable high survival (OS 78.1% vs. 85.6% vs. 73.6%). Lowest survival was observed for patients with p16-negative/HPV-positive OPSCCs (OS 40.8%). Never smoking patients with p16-positive OPSCCs demonstrated the highest survival, whereas within former/current smokers with p16-positive and p16-negative disease it was comparable low (OS 90.0% vs. 63.0% vs. 57.4%). Conclusions p16- and HPV-status should not be considered as equivalent markers for a better prognosis. Furthermore, they should not generally predominate patient associated factors like smoking.
引用
收藏
页码:1983 / 2000
页数:18
相关论文
共 50 条
  • [1] Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma
    Bernhard G. Weiss
    Mahalia Zoe Anczykowski
    Stefan Küffer
    Jennifer L. Spiegel
    Mattis Bertlich
    Martin Canis
    Friedrich Ihler
    Julia Kitz
    Mark Jakob
    European Archives of Oto-Rhino-Laryngology, 2021, 278 : 1983 - 2000
  • [2] The Prognostic Significance of the Biomarker p16 in Oropharyngeal Squamous Cell Carcinoma
    Oguejiofor, K. K.
    Hall, J. S.
    Mani, N.
    Douglas, C.
    Slevin, N. J.
    Homer, J.
    Hall, G.
    West, C. M. L.
    CLINICAL ONCOLOGY, 2013, 25 (11) : 630 - 638
  • [3] Impact of p16, p53, smoking, and alcohol on survival in patients with oropharyngeal squamous cell carcinoma treated with primary intensity-modulated chemoradiation
    Broglie, Martina A.
    Soltermann, Alex
    Rohrbach, David
    Haile, Sarah R.
    Pawlita, Michael
    Studer, Gabriela
    Huber, Gerard F.
    Moch, Holger
    Stoeckli, Sandro J.
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2013, 35 (12): : 1698 - 1706
  • [4] Prognostic significance of non-HPV16 genotypes in oropharyngeal squamous cell carcinoma
    Mazul, Angela L.
    Rodriguez-Ormaza, Nidia
    Taylor, James M.
    Desai, Dipan D.
    Brennan, Paul
    Anantharaman, Devasena
    Gheit, Tarik
    Tommasino, Massimo
    Abedi-Ardekani, Behnoush
    Olshan, Andrew F.
    Zevallos, Jose P.
    ORAL ONCOLOGY, 2016, 61 : 98 - 103
  • [5] Prognostic Significance of p16 Cellular Localization in Oropharyngeal Squamous Cell Carcinoma
    Lai, Syeling
    Wenaas, Ashley E.
    Sandulache, Vlad C.
    Hartman, Christine
    Chiao, Elizabeth
    Kramer, Jennifer
    Zevallos, Jose P.
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2016, 46 (02) : 132 - 139
  • [6] Human Papillomavirus Infection and Prognostic Predictors in Patients with Oropharyngeal Squamous Cell Carcinoma
    Huang, Hui
    Zhang, Bin
    Chen, Wen
    Zhou, Shuang-Mei
    Zhang, Yong-Xia
    Gao, Li
    Xu, Zhen-Gang
    Qiao, You-Lin
    Tang, Ping-Zhang
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (03) : 891 - 896
  • [7] Intensity-Modulated Radiotherapy Outcomes for Oropharyngeal Squamous Cell Carcinoma Patients Stratified by p16 Status
    Shoushtari, Asal
    Meeneghan, Mathew
    Sheng, Ke
    Moskaluk, Christopher A.
    Thomas, Christopher Y.
    Reibel, James F.
    Levine, Paul A.
    Jameson, Mark J.
    Keene, Kimberly
    Read, Paul W.
    CANCER, 2010, 116 (11) : 2645 - 2654
  • [8] Correlation of immune makers with HPV 16 infections and the prognosis in oropharyngeal squamous cell carcinoma
    Zhu, Yingying
    Zhu, Xiaoli
    Diao, Wenwen
    Liang, Zhiyong
    Gao, Zhiqiang
    Chen, Xingming
    CLINICAL ORAL INVESTIGATIONS, 2023, 27 (04) : 1423 - 1433
  • [9] Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma
    Hong, Angela
    Zhang, Xiaoying
    Jones, Deanna
    Veillard, Anne-Sophie
    Zhang, Mei
    Martin, Andrew
    Lyons, J. Guy
    Lee, C. Soon
    Rose, Barbara
    RADIOTHERAPY AND ONCOLOGY, 2016, 118 (02) : 342 - 349
  • [10] Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing
    Nauta, I. H.
    Rietbergen, M. M.
    van Bokhoven, A. A. J. D.
    Bloemena, E.
    Lissenberg-Witte, B., I
    Heideman, D. A. M.
    de Jong, R. J. Baatenburg
    Brakenhoff, R. H.
    Leemans, C. R.
    ANNALS OF ONCOLOGY, 2018, 29 (05) : 1273 - 1279