Copper-Catalyzed Ligand-Free Amidation of Benzylic Hydrocarbons and Inactive Aliphatic Alkanes

被引：73

作者：

Zeng, Hui-Ting ^{[1
]}

Huang, Jing-Mei ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 17期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; METAL-FREE; CHLORAMINE-T; AMINATION; FUNCTIONALIZATION; C(SP(3))-H; AMIDES; INSERTION; SULFOXIMINES; SULFONAMIDES;

D O I：

10.1021/acs.orglett.5b02063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed amidation of benzylic hydrocarbons and inactive aliphatic alkanes with simple amides was developed. The protocol proceeded smoothly without any ligand, and a wide range of N-alkylated aromatic and aliphatic amides, sulfonamides, and imides were synthesized in good yields.

引用

页码：4276 / 4279

页数：4

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