Antiretroviral Concentrations in Hair Strongly Predict Virologic Response in a Large Human Immunodeficiency Virus Treatment-naive Clinical Trial

被引：24

作者：

Gandhi, Monica ^{[1
]}

Bacchetti, Peter ^{[2
]}

Ofokotun, Igho ^{[3
]}

Jin, Chengshi ^{[2
]}

Ribaudo, Heather J. ^{[4
]}

Haas, David W. ^{[5
,6
]}

Sheth, Anandi N. ^{[3
]}

Horng, Howard ^{[1
]}

Phung, Nhi ^{[1
]}

Kuncze, Karen ^{[1
]}

Okochi, Hideaki ^{[7
]}

Landovitz, Raphael J. ^{[8
]}

Lennox, Jeffrey ^{[3
]}

Currier, Judith S. ^{[8
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Div HIV Infect Dis & Global Med, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Biostat, San Francisco, CA USA

[3] Emory Univ, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA

[4] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

[5] Vanderbilt Univ, Div Infect Dis, 221 Kirkland Hall, Nashville, TN 37235 USA

[6] Meharry Med Coll, Dept Internal Med, Nashville, TN 37208 USA

[7] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

[8] Univ Calif Los Angeles, Dept Med, Div Infect Dis, Los Angeles, CA 90024 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HIV; A5257; study; AIDS Clinical Trials Group (ACTG); hair concentrations; non-NNRTI regimens; PREEXPOSURE PROPHYLAXIS; HIV; ADHERENCE; ATAZANAVIR; OUTCOMES;

D O I：

10.1093/cid/ciy764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Concentrations of antiretrovirals in hair are associated with virologic outcomes in cohorts of human immunodeficiency virus (HIV)-positive individuals but have never been examined in a clinical trial. We show for the first time the predictive utility of hair antiretroviral concentrations in a large HIV treatment-naive trial (AIDS Clinical Trials Group protocol A5257).

引用

页码：1044 / 1047

页数：4

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