Chemical encoding of amphiphilic copolymers for a dual controlled release from their assemblies

被引：22
|
作者：
Lv, Li-Ping [1 ]
Zhao, Yi [1 ]
Landfester, Katharina [1 ]
Crespy, Daniel [1 ]
机构：
[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany
来源：
POLYMER CHEMISTRY | 2015年 / 6卷 / 31期
关键词：
DRUG-DELIVERY DEVICES; BLOCK-COPOLYMERS; RAFT POLYMERIZATION; REDOX; MICELLES; POLYMERS; VESICLES; PH; MICELLIZATION; AGGREGATION;
D O I：
10.1039/c4py01159g
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Amphiphilic random copolymers are designed to bear a corrosion inhibitor as cleavable side group, which can be released upon activation by chemical reduction. Polymer nanoparticles are obtained by self-assembly of the copolymers in water. A model dye is encapsulated in the nanoparticles and its release is triggered by reductive cleavage of the copolymer, leading hence to the co-release of the corrosion inhibitor. The present system has the advantage that the cleaved units are functional payloads.
引用
收藏
页码：5596 / 5601
页数：6
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