Decreased plasma nesfatin-1 levels in patients with generalized anxiety disorder

被引：58
作者：
Gunay, Huseyin
Tutuncu, Recep [1 ]
Aydin, Suleyman [2 ]
Dag, Ersel [3 ]
Abasli, Dilek [4 ]
机构：
[1] Etimesgut Asker Hastanesi, Psikiyatri Klin, Dept Psychiat, Ankara, Turkey
[2] Firat Univ, Fac Med, Dept Biochem & Clin Biochem, TR-23169 Elazig, Turkey
[3] Kirikkale Univ, Fac Med, Dept Neurol, Kirikkale, Turkey
[4] Etimesgut Mil Hosp, Dept Clin Biochem, Ankara, Turkey
来源：
PSYCHONEUROENDOCRINOLOGY | 2012年 / 37卷 / 12期
关键词：
Generalized anxiety disorder; Plasma nesfatin-1; Satiety; AMPHETAMINE-REGULATED TRANSCRIPT; NEURONS; STRESS; IDENTIFICATION; DEPRESSION; PEPTIDES; MIDBRAIN; ANOREXIA; HORMONE; NUCLEUS;
D O I：
10.1016/j.psyneuen.2012.04.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nesfatin-1, a recently discovered satiety molecule, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances. However, the relation between nesfatin-1 and stressor related behaviors like anxiety and/or fear has not yet been investigated in human subjects. In the present study, our aim was to investigate whether there was a relationship between plasma nesfatin-1 levels and generalized anxiety disorder. The study group consisted of 40 patients (BMI, 22.98 +/- 0.56) with generalized anxiety disorder and 34 age-matched healthy male control subjects (23.05 +/- 0.4). Patients fully met the fourth Diagnostic and Statistical Manual of Mental Disorders, text revision. Blood samples for nesfatin-1 were drawn at the end of an overnight fasting period at least 10 h. Plasma nesfatin-1 levels were measured and found significantly lower in anxiety disorder group than in control group (0.35 +/- 0.037 ng/ml vs. 0.63 +/- 0.080 ng/ml, respectively, p < 0.05). Low nesfatin-1 levels may be related with generalized anxiety disorder. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1949 / 1953
页数：5
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