CuI/SnCl2 Co-Catalyzed Four-Component Reaction of Ketones, Amines, Alkynes, and Carbon Dioxide

被引：34

作者：

Zhao, Jinwu ^{[1
,2
]}

Huang, Huawen ^{[1
]}

Qi, Chaorong ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China

[2] Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 29期

基金：

中国国家自然科学基金;

关键词：

Ketones; Carbon dioxide fixation; Multicomponent reactions; Heterocycles; Copper; EFFICIENT; ALCOHOLS;

D O I：

10.1002/ejoc.201200990

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four-component CuI and SnCl2 co-catalyzed assembly of ketones, amines, alkynes, and carbon dioxide could be performed in DMSO at 70 degrees C under CO2 pressure to synthesize 5-alkynlene oxazolidinones. It was found that steric hindrance had an extreme effect on the four-component coupling. Aliphatic ketones, basic primary amines, and aryl alkynes were good substrates.

引用

页码：5665 / 5667

页数：3

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